cas 1020-71-9, 4,4'-(DITHIODIMETHYLENE)DIPYRIDINE | Articles data ｜lookchem

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1020-71-9

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N-HETEROCYCLIC COMPOUNDS AS RADIOPROTECTORS II. DERIVATIVES OF PYRIDINE AND PYRIMIDINE CONTAINING THIOL PRECURSORS
Pyridine and 4-substituted pyrimidine derivatives incorporating a sulphur functional side-group were evaluated as potential radioprotective agents by screening tests in mice. 2-(2-Pyridyl)ethanethiol and its derivatives showed some radioprotective action when administered intraperitoneally, but all were inferior to 2-pyridinemethanethiol.They showed no protection when administered orally.Substitution of the pyridine ring by chlorine gave compounds which also showed inferior radioprotective properties to those demonstrated by 2-pyridinemethanethiol.Corresponding phsphorothioates also exhibited little activity.The pyrimidine derivatives showed protection of a low order.Keywords: pyridine derivatives/ pyrimidine derivatives/ thiol/ thiol precursor/ radioprotectors
Barnes, John H.,Fatome, Marc,Jones, Christopher E. L.,Murray, Stephen G.
p. 211 - 216
(2007/10/02)

SYNTHESES OF AMINOTHIOL DERIVATIVES.
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NISHIMURA,TAKAMATSU
p. 944 - 955
(2007/10/04)

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Chemical Properties

Melting Point: 157-158 °C
Boiling Point: 422.4 °C at 760 mmHg
Flash Point:209.3 °C
Density: 1.258 g/cm³
PKA: 5.46±0.10(Predicted)
PSA: 76.38000
LogP: 3.55820

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