Synthesis and cytotoxic activity of 6-(substituted-phenyl)amino-5,8- quinazolinediones
6-Arylamino-5,8-quinazolinediones were synthesized and evaluated for in vitro cytotoxic activity against human solid tumor cell lines A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Most of the 6-arylamino-5,8-quinazolinediones exhibited potent activity against the cell lines HCT-15 and SK-MEL-2. Birkhaeuser Boston 2004.
Ryu, Chung-Kyu,Yi, You-Jin,Choi, Ik Hwa,Chae, Mi Jin,Han, Ja-Young,Jung, Ok-Jai,Lee, Chong-Ock
6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents
A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed.
Park, Hyen Joo,Kim, Young-Shin,Kim, Jin Sung,Lee, Eun-Jin,Yi, You-Jin,Hwang, Hye Jin,Suh, Myung-Eun,Ryu, Chung-Kyu,Lee, Sang Kook
Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives
A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least thre