Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase
Inhibition of soluble epoxide hydrolase (sEH) is hypothesized to lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation of their in vivo pharmacological properties. As part of an effort to identify inhibitors
Eldrup, Anne B.,Soleymanzadeh, Fariba,Taylor, Steven J.,Muegge, Ingo,Farrow, Neil A.,Joseph, David,McKellop, Keith,Man, Chuk C.,Kukulka, Alison,De Lombaert, Stéphane
experimental part
p. 5880 - 5895
(2010/03/24)
Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same
Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
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Page/Page column 25
(2010/11/25)
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