Linking structural dynamics and functional diversity in asymmetric catalysis
Proteins, the functional molecules in biological systems, are sophisticated chemical devices thathave evolved over billions of years. Their function is intimately related to their three-dimensional structure and elegantly regulated by conformational chang
Asymmetric catalysis via dynamic substrate/ligand/rare earth metal conglomerate
A highly enantio- and diastereoselective catalytic asymmetric Mannich-type reaction of α-cyanoketones and N-Boc imines promoted by an amide ligand/Sc(OiPr)3 catalyst is described. The similar reaction outcome is obtained with/without