- Activated Nitriles in Heterocyclic Synthesis: The Reaction of Cyanothioacetamide with Activated Double Bond Systems
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Die Reaktion von Benzylidenmalononitrilen mit Cyanthioacetamid (1) ergibt je nach den Reaktionsbedingungen entweder Thiopyrane oder Pyridine.Die Strukturen der Reaktionsprodukte wurden mittels 13C-NMR aufgeklaert.
- Galil, Fathy Mohamed Abdel,Sallam, Mohamed Mohamed,Sherif, Sherif Mourad,Elnagdi, Mohamed Hilmy
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p. 1639 - 1644
(2007/10/02)
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- Nitriles in Heterocyclic Synthesis: Novel Synthesis of 4H-Thiopyran and of 2-Hydroxy-6-pyridine Thione Derivatives
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Reaction of arylmethylenemalononitrile 2a-c with cyanothioacetamide 1 afforded 4-aryl-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles 5a-c on refluxing in ethanolic aqueous triethylamine, rearranged to yield the 4-aryl-1,2-dihydro-6-hydroxy-2-thioxo-3,5-pyridine dicarbonitriles 8a-c.The same compounds could be obtained on treatment of 2a-c with 1 in ethanolic aqueous triethylamine or on reacting 1 with 2d-f.The 13C NMR data of the products are reported and interpreted. - Keywords: Cyanothioacetamide, 2-Aminothiopyranes, Pyridine Thiones, 13C NMR Spectra
- Elgemeie, Galal Eldin Hamza,Sherif, Sherif Mourad,Aal, Fatma Abd El Maksoud Abd El,Elnagdi, Mohamed Hilmy
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p. 781 - 783
(2007/10/02)
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- A NOVEL SYNTHESIS OF 4-H-THIOPYRANS : UNEXPECTED PRODUCTS OF REACTION OF CYANOTHIOACETAMIDE WITH CINNAMONITRILE DERIVATIVES
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The reaction of arylidenemalononitrile with cynothioacetamide afforded either thiopyrans or pyridine derivatives depending on reaction conditions. 13 C NMR was utilised to elucidate the proposed structures of the reaction products.
- Elgemeie, Galal Eldin Hamza,Sallam, Mohamed Mohamed Mohamed,Sherif, Sherif Mourad,Elnagdi, Mohamed Hilmy
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p. 3107 - 3110
(2007/10/02)
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