- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from Pentoses
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The enyne needed for coupling to a CD-ring fragment, namely, 3S,5R-oct-1-en-7-yne-3,5-diol, in the Trost-Dumas carbopalladation route to 1α,25-dihydroxyvitamin D3 was synthesized from D-xylose in 13 steps and 21percent yield.
- Moriarty, Robert M.,Kim, Joonggon,Brumer, Harry
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- Synthesis of 2-fluoro sugar and its condensation reaction with silylated thymine
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2,3-Dideoxy-2-fluoro-D-erythro-pentofuranose was easily prepared from 3-DPA lactone. The condensation reaction between 1-O-acetyl derivative of this sugar and silylated thymine in the presence of TMSOTf proceeded in a poorly stereoselective manner.
- Niihata,Ebata,Kawakami,Matsushita
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p. 1509 - 1512
(2007/10/02)
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- The Synthesis of the δ-Lactone Portion of the Mevinic Acids; a New Non-acidic Method of Cyclic Lactone Expansion
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An alkoxy-mercuration demercuration sequence has been used as the key step in an enantiospecific synthesis of a protected synthon for the lactone portion of the mevinic acids.
- Davidson, Alan H.,Floyd, Chris D.,Lewis, Christopher N.,Myers, Peter. L.
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p. 1417 - 1418
(2007/10/02)
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- A Tactically Novel Alternative to Acyclic Stereoselection Based on the Concept of a Replicating Chiron - Access to 1,3-Polyols
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(S)-Glutamic acid is used as a chiral template to construct seven carbon subunits containing alternating hydroxyl groups with stereochemical control.Enantiomeric and/or diastereomeric 3,5-dideoxy-heptitols are thus obtained.
- Hanessian, Stephen,Sahoo, Soumya P.,Murray, Peter J.
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p. 5631 - 5634
(2007/10/02)
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