Potential Antitumor Agents. 47. 3'-Methylamino Analogues of Amsacrine with in Vivo Solid Tumor Activity
Replacement of the 3'-methoxy group of the clinical antileukemic agent amsacrine (1) with a 3'-methylamino group provides a compound (3) with a broader spectrum of action, including in vivo activity against experimental solid tumors.The synthesis, physico
Atwell, Graham, J.,Baguley, Bruce C.,Finlay, Graeme J.,Rewcastle, Gordon W.,Denny, William A.