- Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform
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Acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide are potent sub-type selective HDAC6 inhibitors. Constrained heterocyclic analogs based on 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine show further enhanced HDAC6 selectivity and inhibitory activity in ce
- Blackburn, Christopher,Barrett, Cynthia,Brunson, Mable,Chin, Janice,England, Dylan,Garcia, Kris,Gigstad, Kenneth,Gould, Alexandra,Gutierrez, Juan,Hoar, Kara,Rowland, R. Scott,Tsu, Christopher,Ringeling, John,Wager, Krista,Xu, He
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p. 5450 - 5454
(2015/01/08)
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- SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
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This invention provides compounds of formula (I): wherein X1, X2, R1a, R1b, R1c, R1d, n, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention al
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Page/Page column 60
(2011/10/19)
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- SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS
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The object of the present invention is novel substituted pyrrolidine amides of the general formula (I) in which D, L. E, G, J, M, L1, L2, R4, and R5 are defined as in the specification, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, particularly physiologically tolerated salts with inorganic or organic acids or bases having valuable properties.
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Page/Page column 46
(2010/05/13)
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- CARBOXYLIC ACID AMIDES AS FACTOR XA INHIBITORS
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The present invention relates to new substituted carboxylic acid amides of general formula (I), wherein D, B, R3, R4 and R5 are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
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