- AGENT FOR IMPROVING PERMEATION OF A DRUG INTO A NAIL AND AN EXTERNAL TREATING AGENT CONTAINING THE SAME
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The present invention herein provides a compound which promotes drug-permeation into nails. A penetrating promoter comprises, for instance, the following formulas. R1, R2 and R3 are alkyl groups having a carbon number of 1 to 15 and have OH groups at their ends.
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Page/Page column 7
(2010/04/23)
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- Synthesis and helicate formation of a new family of binol-based bis(bipyridine) ligands
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A new family of BINOL-based bis(bipyridine) ligands 1-3 (BINOL = 2,2 -dihydroxy-1,1 -binaphthyl) was prepared in enantiomerically pure form. Whereas the coordination of zinc(ll) ions to these ligands did not result in the selective formation of a specific metallosupramolecular aggregate,1 -3 were found to undergo highly diastereoselective self-assembly to D 2-symmetric dinuclear double-stranded helicates upon coordin ation to silver(l) and copper(l) ions and to D3-symmetric dinuclear triple-stranded helicates upon coordination to iron(ll) as demonstrated by mass spectrometry and by NMR and CD spectroscopy in combination with quantum chemical calculations.
- Bunzen, Jens,Bruhn, Torsten,Bringmann, Gerhard,Luetzen, Arne
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scheme or table
p. 3621 - 3630
(2009/08/14)
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- Surprising substituent effects on the self-assembly of helicates from bis(bipyridyl) BINOL ligands
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(Figure Presented) A number of different bis(bipyridyl) BINOL ligands were prepared using a convergent building block approach. These were studied with regard to their ability to undergo self-assembly to dinuclear helicates upon coordination to suitable late-transition-metal ions. Surprisingly, the substituents at the periphery of the ligand structure were found to have a marked influence on the outcome of the self-assembly processes with regard to the helicates composition, the stereoselectivity of the helicate formation, their redox reactivity, and their electronical properties as scrutinized by NMR- and CD-spectroscopic methods as well as ESI-mass spectrometric methods.
- Bunzen, Jens,Hovorka, Rainer,Luetzen, Arne
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supporting information; scheme or table
p. 5228 - 5236
(2009/12/04)
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- The influence of different spacer lengths on the selectivity of self-assembly processes of bis(bipyridine)-BINOL helicates
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The synthesis and self-assembly behaviour of a series of en-antiomerically pure bis(chelating) ligands is reported. The li-gands differ in the spacer unit between a BINOL core and. two bipyridyl groups as the chelating entities and were found to undergo completely diastereoselective self-assembly to di-nuclear double-stranded helicates with silver(I) salts, as dem-onstrated by NMR and CD spectroscopy and ESI mass spec-trometry. Upon coordination to iron(II) or zinc(II) ions, however, a dramatic loss in the diastereoselectivity of the self-assembly of dinuclear triple-stranded helicates was observed, as a result: of increasing spacer length. In the case of zinc(II), the self-assembly processes were even found, to be nonselec-tive with regard to the composition of the helicates.
- Bunzen, Jens,Hapke, Marko,Luetzen, Arne
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scheme or table
p. 3885 - 3894
(2010/01/18)
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- Synthesis of substituted 2,2′-bipyridines from 2-bromo- or 2-chloropyridines using tetrakis(triphenylphosphine)palladium(0) as a catalyst in a modified Negishi cross-coupling reaction
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A protocol for an efficient, modified Negishi cross-coupling strategy for substituted 2,2′-bipyridines employing tetrakis(triphenylphosphine) palladium(0) as a simple, commercially available, and relatively inexpensive catalyst for both 2-bromo- and 2-chl
- Kiehne,Bunzen,Staats,Luetzen
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p. 1061 - 1069
(2008/02/02)
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- PHOTOCHEMICAL GENERATION OF ALIPHATIC RADICALS FROM BENZOPHENONE OXIME ESTERS: SIMPLE SYNTHESIS OF ALKYLBENZENES AND ALKYLPYRIDINES
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Photolysis of benzophenone oxime esters, prepared with aliphatic carboxylic acids and benzophenone oxime, in benzene and pyridine generates various primary, secondary and tertiary aliphatic radicals selectively, and corresponding alkylbenzenes and alkylpyridines are produced in good yields, respectively.
- Hasebe, Masato,Tsuchiya, Takashi
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p. 3239 - 3242
(2007/10/02)
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