- Structure activity studies on sulfamate sweeteners
-
The structure activity relationships governing sulfamate sweeteners are reviewed under the headings: size of the reduced ring, changes in the sulfamate function, substitution of hydrogen in the ring, and substitution of carbon in the ring and open chain c
- Benson,Spillane
-
-
Read Online
- Potent and selective, sulfamide-based human β3-adrenergic receptor agonists
-
A series of sulfamide-based analogs related to L-796568 were prepared and evaluated for their biological activity at the human β3- adrenergic receptor (AR). This modification allows for a significant reduction in molecular weight, while maintai
- Dow, Robert L.,Paight, Ernest S.,Schneider, Steven R.,Hadcock, John R.,Hargrove, Diane M.,Martin, Kelly A.,Maurer, Tristan S.,Nardone, Nancy A.,Tess, David A.,DaSilva-Jardine, Paul
-
p. 3235 - 3240
(2007/10/03)
-
- THROMBIN INHIBITORS
-
The present invention relates to a compound having formula I:and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhibitors which are useful as anticoagulants.
- -
-
-
- Thrombin inhibitors
-
The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhibitors which are useful as anticoagula
- -
-
-
- Chemical and Biological Reactivity of Sulfamidopenicillins
-
A number of semisynthetic penicillins bearing a sulfamido side chain at the 6-position have been prepared and their chemical and biological reactivity examined.The compounds do not show antibiotic activity against Escherichia coli but do show activity aga
- Davern, Peter,Sheehy, James,Smyth, Timothy
-
p. 381 - 388
(2007/10/02)
-
- BASICITY OF NITROGEN-SULPHUR(VI) COMPOUNDS. PART 5. IONIZATION OF TRISUBSTITUTED SULPHAMIDES
-
The ionization equilibria in base of 27 trisubstituted sulphamides, mainly represented by the following series: X-C6H4NHSO2NR2R1, where NR2R1=piperidyl, morpholinyl, and NnPr2, and RHNSO2NR2R1/s
- McDermott, Sean D.,Burke, Padraig O.,Spillane, William J.
-
p. 499 - 502
(2007/10/02)
-
- Versatile Synthesis of Sulphamate Esters by Phase-transfer Methods
-
The syntheses of sulphamate esters of the general types R1R2NSO3R3, RNHSO3R3, and H2NSO3R3, where R3 may be aliphatic or aromatic, have been achieved in good yield by reaction of the appropriate sulphamoyl chlorides with alcohols and phenols under mild phase-transfer conditions.The present methods have led to generally higher yields, and to shorter reaction times and lower reaction temperatures than were hitherto found necessary.The prior preparation of the alkoxide has also been obviated.Some esters have been rearranged to the isomeric betaines.
- Spillane, William J.,Taheny, Anne P.,Kearns, M. Mary
-
p. 677 - 680
(2007/10/02)
-
- Manufacture of sulfamic acid halides
-
Sulfamic acid halides are produced by reaction of sulfamic acids with phosphorus pentahalide in the presence of phosphorus oxyhalide in specific molar ratios and in the presence of halohydrocarbons. The products, some of which are new compounds, are starting materials for the manufacture of plant protection agents, dyes and pharmaceuticals.
- -
-
-
- N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same
-
The case involves novel N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same. The N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidines are excellent eukalemic agents possessing diuretic and natriuretic properties.
- -
-
-