- ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.
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Paragraph 0230; 0234; 0235; 0236; 0611; 0612; 0613
(2017/06/12)
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- General and cost-effective synthesis of 1-heteroaryl/arylcycloalkylamines and their broad applications
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A general and cost-effective route has been developed to synthesize 1-heteroarylsubstituted cycloalkylamines from readily available heteroarylacetate in good yields. This synthesis features a LHMDS promoted cyclization and one-pot hydrolysis/Curtius rearr
- Zhang, Dehui,Zheng, Hongchao,Wang, Xiaodong
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p. 1941 - 1953
(2016/04/05)
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- ANTITUMOR EFFECT POTENTIATOR COMPOSED OF IMIDAZOOXAZINE COMPOUND
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An antitumor effect potentiator for potentiating one or more other antitumor agents, comprising, as an active ingredient, an imidazooxazine compound represented by Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, B, C, and D represen
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- PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE
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The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:
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- NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF
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The present invention provides an imidazooxazine compound represented by Formula (I) or a salt thereof, wherein A, B, C, and D are as defined in the specification.
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- SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS
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Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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Page/Page column 48
(2013/07/25)
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- SUBSTITUTED PYRAZOLOPYRIMIDINES AS AKT KINASE INHIBITORS
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Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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Page/Page column 47
(2013/07/25)
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- BICYCLIC PYRIMIDINES
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Compounds of formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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- IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS
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Imidazopyridazines of formula (I) a process for their production and the use thereof.
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- SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AND -PYRIDINES
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Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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Page/Page column 86
(2012/02/02)
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- Inhibitors of Akt activity
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The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
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Page/Page column 59
(2008/12/06)
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