Novel antibacterially active 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acids of the formula STR1 in which R1 is hydrogen, methyl or ethyl, and R2 is hydrogen or fluorine, and pharmaceutically tolerable hydrates and salts thereof.
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(2008/06/13)
Isolation and structural elucidation of urinary metabolites of ciprofloxacin
After oral administration of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-1-ylqu inoline-3-carboxylic acid (ciprofloxacin, Bay o 9867; designated trademark: Ciprobay) four metabolites M1-M4 were isolated from human urine by Craig counter current distribution and semipreparative high-performance liquid chromatography. Their molecular structures were elucidated by nuclear magnetic resonance and mass spectrometry and confirmed by comparing their spectra with those of authentic synthetic reference compounds.
Gau,Kurz,Petersen,Ploschke,Wuensche
p. 1545 - 1549
(2007/10/02)
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