Novel 2′-alkoxymethyl substituted klavuzon derivatives as inhibitors of Topo I and CRM1
In this work, 2′-alkoxymethyl substituted klavuzon derivatives were prepared starting from 2-methyl-1-naphthoic acid in eight steps. Anticancer potencies of the synthesized compounds were evaluated by performing MTT cell viability test over cancerous and
?etinkaya, Hakk?,Y?ld?z, Mehmet S.,Kutluer, Meltem,Alkan, Aylin,Ozan Ota?, Hasan,?a??r, Ali
Liquid Chromatographic Optical Resolution of 2,2'-Spirobibenzindan Derivatives and Absolute Stereochemistry as Determined by the C.D. Exciton Chirality Method
2,2'-Spirobibenzindan derivatives, (1) and (2) have been synthesized and optically resolved by means of liquid chromatography using a column with a chiral stationary phase of (+)-poly(triphenylmethyl methacrylate); the absolute stereochemistry of each enantiomer was unambiguously determined by the c.d. exciton chirality method.