- A process for preparing high-purity lisinopril
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The invention provides a method for synthesizing high purity lisinopril, using L - proline weakly alkaline compound ammonium salt to replace the L - proline in the strong alkali compound salt (such as tetramethyl ammonium hydroxide, sodium hydroxide), (II) with the lisinopril hydride in the DCC and N - hydroxy succinimide (NHS) in the presence of a condensation, hydrolysis to obtain the lisinopril. The preparation method from the source control the specific impurity N6 - (3 - Carboxyl propionyl) lisinopril (I) generating, so that the obtained lisinopril and its dihydrate pharmaceutical standards, is suitable for industrial production.
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Paragraph 0045-0074
(2019/05/15)
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