Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells
Carboxylesterase 2 (CES2) is one of the most important Phase I drug metabolizing enzymes in the carboxylesterase family. It plays crucial roles in the bioavailability of oral ester prodrugs and the therapeutic effect of some anticancer drugs such as irino
Design, Synthesis, and Structure-Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase
Pancreatic lipase (PL), a key target for the prevention and treatment of obesity, plays crucial roles in the hydrolysis and absorption of in dietary fat. In this study, a series of pyrazolones was synthesized, and their inhibitory effects against PL were
Zhang, Jing,Yang, Yang,Qian, Xing-Kai,Song, Pei-Fang,Zhao, Yi-Shu,Guan, Xiao-Qing,Zou, Li-Wei,Bao, Xiaoze,Wang, Hong
supporting information
p. 1600 - 1604
(2021/03/03)
The first successful intermolecular Heck reaction of Baylis-Hillman adducts: synthesis of β-aryl substituted Baylis-Hillman adducts
The first successful intermolecular Heck reaction between Baylis-Hillman adducts and aryl iodides was achieved under the conditions comprising Pd(OAc)2/n-Bu4NBr/KOAc in CH3CN.
Kim, Jeong Mi,Kim, Ko Hoon,Kim, Taek Hyeon,Kim, Jae Nyoung
p. 3248 - 3251
(2008/09/21)
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