Soluble alpha-amino acid salts in acetonitrile: practical technology for the production of some dipeptides.
Alpha-amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibitor enalapril. [reaction: see text]
Palomo, Claudio,Palomo, Antonio L,Palomo, Francisco,Mielgo, Antonia
p. 4005 - 4008
(2007/10/03)
Process for preparing an angiotensin converting enzyme inhibitor
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(2008/06/13)
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