- Synthesis of new C3h and C3v truxene derivatives
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Palladium-catalyzed cross coupling of 2,7,12-tribromotruxene with organostannanes and boronic acids leads to 2,7,12-trisubstituted truxenes. 5,10,15-Tdarylated and trialkynylated truxene derivatives are obtained by the reaction of truxenone with aryl Grignard reagents or an alkynyllithium, followed by reduction of the tertiary alcohols with Et3SiH or BF3. syn-5,10,15-Triarylated derivatives were obtained by the base-catalyzed isomerization of the anti derivatives.
- Go?mez-Lor, Berta,De Frutos, O?scar,Ceballos, Pla?cido A.,Granier, Thierry,Echavarren, Antonio M.
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- A Convenient Synthesis of 7-Halo-1-indanones and 8-Halo-1-tetralones
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A regioselective oxidation of N-indan-4-yl-acetamide or N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide with potassium permanganate followed by acidic hydrolysis gave 7-aminoindan-1-one or 8-aminotetral-1-one in good yield. The amino ketones were converted to the corresponding 7-haloindanone or the 8-halotetralone. Another method to prepare 7-haloindan-1-ones was completed by a cyclization of 3-chloro-1-(2-halophenyl)propan-1-one under Friedel-Crafts conditions to produce the product in gram quantity.
- Nguyen, Phong,Corpuz, Evelyn,Heidelbaugh, Todd M.,Chow, Ken,Garst, Michael E.
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p. 10195 - 10198
(2007/10/03)
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