- Synthesis and Evaluation of N,N-Di-n-propyltetrahydrobenzindol-7-amine and Related Congeners as Dopaminergic Agonists
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An evaluation of 6-indole (4), its rigid analogue N,N-di-n-propyl-5,6,7,8-tetrahydrobenzindol-7-amine (5), and some related congeners, for ability to suppress serum prolactin in reserpinized rats, revealed modest biological a
- Nichols, David E.,Cassady, John M.,Persons, Paul E.,Yeung, Ming C.,Clemens, James A.,Smalstig, E. Barry
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p. 2128 - 2134
(2007/10/02)
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- 4--2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist
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4--2(3H)-indolone (1c) (SK and F 101468) is a potent and selective prejunctional dopamine receptor agonist.It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (EC50 = 100 nM), and this response was antagonized by (S)-sulpiride (KB = 7 nM).Compound 1c did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce stimulation of the central nervous system in rats.It was prepared from (2-methyl-3-nitrophenyl)acetic acid in a multistep sequence based on the Reissert indole synthesis.
- Gallagher, Gregory,Lavanchy, Patricia G.,Wilson, James W.,Hieble, J. Paul,DeMarinis, Robert M.
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p. 1533 - 1536
(2007/10/02)
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