- Light-triggered reversible "one-to-two" morphological transition in a "latent double-amphiphilic" linear-hyperbranched supramolecular block copolymer
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This study reports a new category of stimuli-responsive morphological transitions, i.e., from one morphology (e.g., vesicles) to another two different ones (e.g., nanosheets and nanofibers), by investigating the light-responsive self-assembly behaviour of a "latent double-amphiphilic" linear-hyperbranched supramolecular block copolymer.
- Jiang, Wenfeng,Liu, Yong,Yu, Chunyang,Li, Shanlong,Li, Yongjin,Zhou, Yongfeng
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- Azobenzene abamectin derivative and preparation method and application thereof
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The invention relates to an azobenzene abamectin derivative and preparation and application thereof. Specifically, the invention discloses a compound with a formula (I) or an optical isomer, a cis-trans-isomer or an agricultural pharmacologically acceptable salt thereof, and a preparation method thereof. The invention further discloses an agricultural composition containing the compound and application of the agricultural composition. The derivative has high killing activity on agricultural pests, mites and the like, and can be used for preventing and treating the pests.
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Paragraph 0150; 0157-0159
(2021/07/24)
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- Azologization of serotonin 5-HT3 receptor antagonists
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The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-HT3 receptor is related to chemo-/radiotherapy provoked emesis and dysfunction leads to neurodevelopmental disorders and psychopathologies. Since the development of the first serotonin receptor antagonist in the early 1990s, the range of highly selective and potent drugs expanded based on various chemical structures. Nevertheless, on-off-targeting of a pharmacophore’s activity with high spatiotemporal resolution as provided by photopharmacology remains an unsolved challenge bearing additionally the opportunity for detailed receptor examination. In the presented work, we summarize the synthesis, photochromic properties and in vitro characterization of azobenzene-based photochromic derivatives of published 5-HT3R antagonists. Despite reported proof of principle of direct azologization, only one of the investigated derivatives showed antagonistic activity lacking isomer specificity.
- Rustler, Karin,Maleeva, Galyna,Bregestovski, Piotr,K?nig, Burkhard
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p. 780 - 788
(2019/04/17)
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