Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors
Previous structure-based design studies resulted in the discovery of alkyl substituted diphenyl ether inhibitors of InhA, the enoyl reductase from Mycobacterium tuberculosis. Compounds such as 5-hexyl-2-phenoxyphenol 19 are nM inhibitors of InhA and inhib
am Ende, Christopher W.,Knudson, Susan E.,Liu, Nina,Childs, James,Sullivan, Todd J.,Boyne, Melissa,Xu, Hua,Gegina, Yelizaveta,Knudson, Dennis L.,Johnson, Francis,Peloquin, Charles A.,Slayden, Richard A.,Tonge, Peter J.
p. 3029 - 3033
(2008/12/23)
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