- Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs
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Cancer cells produce elevated levels of reactive oxygen species, which has been used to design cancer specific prodrugs. Their activation relies on at least a bimolecular process, in which a prodrug reacts with ROS. However, at low micromolar concentratio
- Daum, Steffen,Reshetnikov, M. S. Viktor,Sisa, Miroslav,Dumych, Tetyana,Lootsik, Maxim D.,Bilyy, Rostyslav,Bila, Evgenia,Janko, Christina,Alexiou, Christoph,Herrmann, Martin,Sellner, Leopold,Mokhir, Andriy
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supporting information
p. 15545 - 15549
(2017/11/16)
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- ANTIULCER BENZIMIDAZOLE DERIVATIVES
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Compounds of formula I STR1 in which R 1 and R 2, which may be the same or different, are hydrogen, a C 1 to C 3 alkyl group or R 1 and R 2 together with the nitrogen to which they are attached form an optionally substituted heterocyclic ring; R 3 and R. sub.4, which may be the same or different are hydrogen, a C 1 to C. sub.3 alkyl or an optionally substituted C 3 to C 6 cycloalkyl group, or R 3 and R 4 together with the nitrogen to which they are attached form an optionally substituted heterocyclic ring; m is 0, 1 or 2; p is 0, 1 or 2; E is an alkylene group connected to or interrupted by an oxygen or a sulphur atom; J is hydrogen or a substituent group; and their pharmaceutically acceptable salts have utility as histamine H 2-receptor antagonists.
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