Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation
Synthesis and structure-activity relationships of cannabinoid-1 receptor (CB1R) inverse agonists based on dihydro-pyrano[2,3-b] pyridine and tetrahydro-1,8-naphtyridine scaffolds are presented. Rat food intake and pharmacokinetic evaluation of 13g, 13i, 1
Madsen-Duggan, Christina B.,Debenham, John S.,Walsh, Thomas F.,Yan, Lin,Huo, Pei,Wang, Junying,Tong, Xinchun,Lao, Julie,Fong, Tung M.,Xiao, Jing Chen,Huang, Cathy R.-R.C.,Shen, Chun-Pyn,Stribling, D.Sloan,Shearman, Lauren P.,Strack, Alison M.,Goulet, Mark T.,Hale, Jeffrey J.
scheme or table
p. 3750 - 3754
(2010/09/03)
SUBSTITUTED PYRANO[2,3-B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS
Novel compounds of the structural Formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
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Page/Page column 99-100
(2008/12/07)
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