Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation
Synthesis and structure-activity relationships of cannabinoid-1 receptor (CB1R) inverse agonists based on dihydro-pyrano[2,3-b] pyridine and tetrahydro-1,8-naphtyridine scaffolds are presented. Rat food intake and pharmacokinetic evaluation of 13g, 13i, 1
Madsen-Duggan, Christina B.,Debenham, John S.,Walsh, Thomas F.,Yan, Lin,Huo, Pei,Wang, Junying,Tong, Xinchun,Lao, Julie,Fong, Tung M.,Xiao, Jing Chen,Huang, Cathy R.-R.C.,Shen, Chun-Pyn,Stribling, D.Sloan,Shearman, Lauren P.,Strack, Alison M.,Goulet, Mark T.,Hale, Jeffrey J.
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
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Page/Page column 99-100
(2008/12/07)
SUBSTITUTED PYRANO[2,3-B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS
Novel compounds of the structural Formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
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Page/Page column 41-42
(2008/12/07)
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