Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 receptor antagonist ELN441958
The bradykinin B1 receptor plays a critical role in chronic pain and inflammation, although efforts to demonstrate efficacy of receptor antagonists have been hampered by species-dependent potency differences, metabolic instability, and low oral
Hawkinson, Jon E.,Szoke, Balazs G.,Garofalo, Albert W.,Hom, Dennis S.,Zhang, Hongbing,Dreyer, Mark,Fukuda, Juri Y.,Chen, Linda,Samant, Bhushan,Simmonds, Stellanie,Zeitz, Karla P.,Wadsworth, Angie,Liao, Anna,Chavez, Raymond A.,Zmolek, Wes,Ruslim, Lany,Bova, Michael P.,Holcomb, Ryan,Butelman, Eduardo R.,Ko, Mei-Chuan,Malmberg, Annika B.
Novel compounds useful for bradykinin B1 receptor antagonism
Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor.
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(2010/11/25)
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