Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors
Novel triazoloquinazolines have been found as phosphodiesterase 10A (PDE10A) inhibitors. Structure-activity studies improved the initial micromolar potency which was found in the lead compound by a 100-fold identifying 5-(1H-benzoimidazol-2-ylmethylsulfan
Kehler, Jan,Ritzen, Andreas,Langgard, Morten,Petersen, Sebastian Leth,Farah, Mohamed M.,Bundgaard, Christoffer,Christoffersen, Claus Tornby,Nielsen, Jacob,Kilburn, John Paul
scheme or table
p. 3738 - 3742
(2011/07/31)
Structure-Activity Profile of a Series of Novel Triazoloquinazoline Adenosine Antagonists
During a search for benzodiazepine receptor modulators, a highly potent adenosine antagonist (CGS 15943) was discovered.The compound was defined as resonance-stabilized hybrid of the canonical structures 9-chloro-2-(2-furyl)triazoloquinazoli
Francis, John E.,Cash, William D.,Psychoyos, Stacy,Ghai, Geetha,Wenk, Paul,et al.
p. 1014 - 1020
(2007/10/02)
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