- Gas-Phase Kinetics of Elimination Reactions of Pentane-2,4-Dione Derivatives
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Gas-phase elimination reactions of pentane-2,4-dione, methyl acetoacetate, ethyl acetoacetate, 3-phenylhydroazopentane-2,4-dione, and ethyl 3-oxo-2-phenylhydrazonobutyrate have been measured in the temperature ranges of 744-783, 662-695, 614-663, 604-664, and 503-555 K, respectively, using a flow-thermolysis technique.These compounds undergo unimolecular first-order elimination reactions, for which log A = 11.9, 11.2, 11.7, 11.5, and 11.7 s-1 and Ea = 198.3, 167.1, 141.7, 165.6, and 141.7 kJ mol-1, respectively.The kinetic data and product analysis shows that the reactions are highly affected by the electronic nature of the substituents at the carbonyl and methylene carbon atoms of the substrates investigated.
- Al-Awadi, Nouria A.,El-Nagdi, Mohamed H.,Mathew, Tommy
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- Efficient synthesis and In Silico study of some novel pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine derivatives
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A novel series of 1,5-dihydropyrido-triazolo-pyrimidine derivatives were prepared by cyclocondensation of 2-thioxo-pyrido[2,3-d]pyrimidines (prepared from reaction of chalcone with 6-aminothiouracil) with a variety of hydrazonoyl chlorides. Based on spect
- Abdelrazek, Fathy M.,Gomha, Sobhi M.,Abdel-aziz, Hassan M.,Farghaly, Mohamed S.,Metz, Peter,Abdel-Shafy, Ahmed
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- Synthesis of Bicyclic Boron Heterocycles Containing [1,3,4,2]Oxadiazaborole and [1,3,2]Oxazaborine
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Boron triacetate, generated in situ, reacts with various 3-(2-acylhydrazono)-2-(2-phenylhydrazono)butanoic acids to give 4-acetoxy-2-aryl-8-methyl-6-oxo-7-phenylhydrazono-2H,4H,6H,7H,8H-[1,3,4,2]oxadiazaborolo[2,3-b][1,3,2]oxazaborines in good yields. These derivatives represent a class of new zwitterionic, tetrahedral boron heterocycles. X-ray single-crystal analyses of one of the starting (acylhydrazono)butanoic acids as well as of one heterocyclic boron product are reported.
- Kotali, Antigoni,Maniadaki, Anna,Kotali, Elvira,Harris, Philip A.,Rózycka-Soko?owska, Ewa,Ba?czewski, Piotr,Joule, John A.
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- Synthesis of arylhydrazone-based molecular switches using aryldiazonium silica sulfate nanocomposites and analysis of their isomerization
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A fast and efficient method for the synthesis of a series of arylhydrazones by reacting aryldiazonium silica sulfate nanocomposites with malononitrile, ethyl acetoacetate and dimedone is reported. All reactions were carried out in water at room temperature and the corresponding products were obtained in 77–87% yields. The existence of two kinds of intramolecular hydrogen bonds in the arylhydrazones synthesized using ethyl acetoacetate enables these compounds to be switched by rotation about the hydrazone C[dbnd]N bond, which leads to a reversible isomerization between their E and Z configurations. This switching can be controlled by changing the polarity of the solvents. The E/Z ratio of each synthesized compound was studied in CHCl3 and DMSO. The ratios of the E/Z were calculated using 1H NMR data in both CDCl3 and DMSO?d6, and used to calculate ΔG° for the E-Z isomerization of each synthesized compound in these two solvents. By changing the solvent from CHCl3 to DMSO, the E/Z ratios decreased. The results demonstrated that the ΔG° values for the formation of Z isomers were more negative than those of the E isomers in DMSO. This is why Z isomers are more stable than E isomers in DMSO. The results of density functional theory (DFT) calculations at B3LYP/6–311++G (d,p) level of theory, were in agreement with the experiments and confirmed the increased stability of Z isomers in DMSO. In most cases, DFT calculation in CDCl3 and DMSO indicate that the dipole moments of the Z isomers are significantly higher than those of the E isomers. Finally, the effect of temperature on the E-Z isomerization was studied using dynamic 1H NMR. The findings demonstrated that temperature does not have any significant effect on the E-Z isomerization in CDCl3 and DMSO?d6.
- Abbaspourrad, Alireza,Aghaei, Hamidreza,Chermahini, Alireza Najafi,Khazdooz, Leila,Soltani, Solmaz,Zarei, Amin
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- Preparation method and application of compound containing zinc-bound and quinoline skeleton
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The invention relates to the field of pharmaceutical chemistry, in particular to a novel zinc-containing binding group-containing quinoline compound. A geometric isomer, a pharmaceutically acceptable salt, solvate or prodrug thereof, a preparation method and thereof, and a pharmaceutical composition containing the compound. The invention also relates to an application of the compound in preparation of drugs for treating and/or preventing diseases mediated by c-Met tyrosine kinase and HDAC. The quinoline compounds, geometric isomers and pharmaceutically acceptable salts, solvates and prodrugs thereof are shown in the specification, and R. 1 , m, Q, X, As described in the claims and the description.
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Paragraph 0114; 0119-0121
(2021/11/10)
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- Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists
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Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid–leucine–arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block
- Chu, Bizhu,Jiang, Yuyang,Li, Qinyuan,Liu, Zijian,Luo, Jingyi,Shi, Zhichao,Xin, Qilei,Ye, Lizhen,Zhan, Feng,Zhang, Xun,Zhu, Qingyun
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- 4-phenoxy pyridine derivative containing 3-pyridazinone structure, 4-pyridazinone structure and 1,2,4-triazinone structure, and applications thereof.
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The invention relates to a 4-phenoxy pyridine derivative containing a 3-pyridazinone structure, a 4-pyridazinone structure and a 1,2,4-triazinone structure, and applications thereof. According to theinvention, the 4-phenoxy pyridine derivative has a struc
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Paragraph 0062; 0070-0071
(2020/02/04)
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- Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors
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Three series of novel 4-phenoxypyridine derivatives containing 4-methyl-6-oxo-1,6-dihydropyridazine- 3-carboxamide, 5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxamide and 4-methyl-3,5-dioxo-2,3,4,5- tetrahydro-1,2,4-triazine-6-carboxamide moieties were synthesized and evaluated for their in vitro inhibitory activitives against c-Met kinase and cytotoxic activitives against A549, H460, HT-29 cancer cell lines. The results indicated that most of the compounds showed moderate to good antitumor activitives. The most promising compound 26a (with c-Met IC50 value of 0.016 μM) showed remarkable cytotoxicity against A549, H460, and HT-29 cell lines with IC50 values of 1.59 μM, 0.72 μM and 0.56 μM, respectively. Their preliminary structure-activity relationships (SARs) studies indicate that 4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide was more preferred as linker part, and electron-withdrawing groups on the terminal phenyl rings are beneficial for improving the antitumor activitives. Furthermore, the colony formation, acridine orange/ethidium bromide (AO/EB) staining, apoptosis, and wound-healing assay of 26a were performed on HT-29 and/or A549 cell lines.
- Chen, Ye,Ding, Shi,Gong, Yilin,Hao, Xuechen,Hou, Yunlei,Liu, Ju,Liu, Yajing,Shi, Jiantao,Wang, Yang,Zhou, Yunpeng
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- Design, synthesis and biological evaluation of 4-(pyridin-4-yloxy)benzamide derivatives bearing a 5-methylpyridazin-3(2H)-one fragment
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A series of 4-(pyridin-4-yloxy)benzamide derivatives bearing a 5-methylpyridazin-3(2H)-one fragment were designed, synthesized, and evaluated for their biological activity. Most compounds showed effective inhibitory activity against cancer cell lines of A
- Duan, Yongli,Tang, Qidong,Xiong, Hehua,Zhang, Han,Zhang, Jianqing,Zhang, Qian,Zheng, Pengwu
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- Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors
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Clinically, a single agent that simultaneously inhibits multiple targets has been widely used in cancer treatment to overcome complicated dose design and anti-cancer resistance. Inspired by the synergistic effects between c-Met and HDAC in tumor developme
- Hu, Hao,Chen, Fei,Dong, Yuhong,Li, Ming,Xu, Sicong,Qin, Mingze,Gong, Ping
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- Synthesis and bioevaluation study of novel N-methylpicolinamide and thienopyrimidine derivatives as selectivity c-Met kinase inhibitors
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Four series of N-methylpicolinamide moiety and thienopyrimidine moiety bearing pyridazinone were designed and synthesized and evaluated for the IC50 values against three cancer cell lines (A549, HepG2 and MCF-7) and some selected compounds were
- Wang, Linxiao,Xu, Shan,Chen, Xiuying,Liu, Xiaobo,Duan, Yongli,Kong, Dejia,Zhao, Dandan,Zheng, Pengwu,Tang, Qidong,Zhu, Wufu
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p. 245 - 256
(2017/12/06)
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- Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies
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A series of newly synthesized 4-aryl-hydrazonopyrazolones were designed and their structures were confirmed by spectral and elemental analyses. All synthesized compounds were evaluated for their in vitro COXs, 5-LOX inhibition, in vivo analgesic and anti-
- Abdelgawad, Mohamed A.,Labib, Madlen B.,Ali, Waleed A.M.,Kamel, Gehan,Azouz, Amany A.,EL-Nahass, EL-Shaymaa
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p. 103 - 114
(2018/03/21)
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- Preparation and application of thiophene pyrimindine compound containing heteroaryl amide structure
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The invention relates to a thiophene pyrimindine compound containing a heteroaryl amide structure shown in the general formula I, and a pharmaceutically acceptable salt, an aquo-complex, a solvate and a predrug of the thiophene pyrimindine compound containing the heteroaryl amide structure, wherein the implications of the substituent group R1, X, Y, D and Z are shown in the description. The invention further relates to a strong effect of inhibiting c-Met kinase of the compound shown in the general formula I, and also relates to application of the compound and the pharmaceutically acceptable salt, the aquo-complex, the solvate and the predrug of the thiophene pyrimindine compound to preparing a medicine used for treating diseases caused by abnormal high expression of the c-Met kinase, particularly application to preparing a medicine for treating and/or preventing cancers.
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Paragraph 0192; 0193
(2017/10/25)
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- Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors
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A series of 7-azaindole derivatives bearing the dihydropyridazine scaffold were synthesized and evaluated for their c-Met kinase inhibitory, and antiproliferative activity against 4 cancer cell lines (HT29, A549, H460, U87MG) were evaluated in?vitro. Most compounds showed moderate to excellent potency. Compared to foretinib, the most promising analog 34 (c-Met IC50: 1.06?nM, a multitarget tyrosine kinase inhibitor) showed a 6.4-, 7.8-, and 3.2-fold increase in activity against HT29, A549, and H460?cell lines, respectively. Structure activity relationship studies indicated that mono-EWGs (such as R2?=?F) at 4-position of moiety D was a key factor in improving the antitumor activity.
- Tang, Qidong,Wang, Linxiao,Duan, Yongli,Wang, Wenhui,Huang, Shunmin,Zhi, Jia,Jia, Shuang,Zhu, Wufu,Wang, Ping,Luo, Rong,Zheng, Pengwu
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- Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors
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In continue to our previous research, eight series of pyrrolo[2,3-b]pyridine and pyrrolo[2,3-d]pyrimidine derivatives bearing pyridazinone moiety were designed, synthesized, and the in vitro antitumor activity was evaluated against four cancer cell lines (A549, HepG2, MCF-7 and PC-3). Some selected compounds (22f, 22g, 26c and 26e) were evaluated for the activity against c-Met kinase, and according to the results of kinase inhibitory activity, the compound 22g was further evaluated for other four tyrosine kinases (Flt-3, VEGFR-2, c-Kit and EGFR) to test the enzyme-based selectivity. The most promising compound 22g showed excellent activity than lead compound Foretinib against A549, HepG2, MCF-7 and PC-3 cell lines, with the IC50 values of 2.19 ± 0.45 μM, 1.32 ± 0.26 μM, 6.27 ± 1.04 μM and 4.63 ± 0.83 μM. The structure–activity relationships (SARs) and docking studies indicated that the pyrrolo[2,3-b]pyridine derivatives bearing 4-oxo-pyridazinone moiety was superior to the pyrrolo[2,3-d]pyrimidine derivatives bearing 6-oxo-pyridazinone moiety. What's more, the target compounds modified with X and Y (X = H, Y = H) were favorable to the activity. And electron drawing groups (EWGs) of 4-Cl-3CF3 on the aryl group show the best activity.
- Wang, Lin Xiao,Liu, Xiaobo,Xu, Shan,Tang, Qidong,Duan, Yongli,Xiao, Zhen,Zhi, Jia,Jiang, Liwen,Zheng, Pengwu,Zhu, Wufu
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p. 538 - 551
(2017/11/01)
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- Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents
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A series of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety were synthesized and evaluated for their in vitro cytotoxic activity against five cancer cell lines (HT-29, H460, A549, MKN-45, and U87MG). Most of the compounds exhibited moderate-to-significant cytotoxicity and high selectivity against one or more cell lines. Compounds 15a, 20a, 15b, 15c, 20d, and 16e were further examined for their inhibitory activity against c-Met kinase. The most promising compound 15a (c-Met half-maximal inhibitory concentration [IC50] = 2.15 nM) showed remarkable cytotoxicity against HT-29, H460, and A549 cell lines with IC50 values of 0.10 μM, 0.13 μM, and 0.05 μM, respectively, and thus it was 1.5- to 2.3-fold more potent than foretinib. Their preliminary structure-activity relationships (SARs) studies indicate that electron-withdrawing groups on the terminal phenyl rings are beneficial for improving the antitumor activity.
- Zhou, Shunguang,Liao, Huimin,He, Chao,Dou, Yanan,Jiang, Mingyan,Ren, Lixiang,Zhao, Yanfang,Gong, Ping
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p. 581 - 593
(2014/07/21)
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- Mechanically activated solid-state synthesis of phenylhydrazone derivatives via high-speed ball milling
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A series of phenylhydrazone derivatives was synthesized from arenediazonium tetrafluoroborates and active methylene compounds under high-speed ball milling. The reaction occurred in the absence of the solvent and products were obtained in good yield within short reaction times (no more than 30 min).
- Zhu, Xingyi,Chen, Yuanyuan,Chen, Yuhe,Wang, Jue,Su, Weike
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p. 621 - 626
(2014/07/21)
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- Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus
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A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10 μg ml-1 in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies.
- Bandyopadhyay, Prabal,Guha, Lopamudra,Seenivasagan,Sathe, Manisha,Sharma, Pratibha,Parashar,Kaushik
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supporting information; experimental part
p. 794 - 797
(2011/03/18)
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- Synthesis, characterization and antibacterial screening of new pyrazole and pyrazoline-5-one derivatives
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A series of N′-(p-toluene sulphonyl)-3-methyl-4-(substituted arylhydrazono)-2-pyrazoline-5-ones and N′-(2-hydroxybenzoyl)-3,5-dimethyl- 4-(substituted arylazo)pyrazoles have been synthesized and characterized by chemical analysis, IR and 1H NMR spectral data. The compounds have been screened for antibacterial activity against Staphylococcus aureus and Escherichia coli.
- Nagaraju,Srinivasulu,Doraswamy,Venkata Ramana
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experimental part
p. 293 - 298
(2012/03/11)
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- Synthesis of some substituted pyrazolones
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Ethyl-2-[diazo (substituted benzene)] acetoacetates II were treated with thiosemicarbazide to furnish 4-(substituted phenyl) azo-5-methyl-2-thioamido-3- pyrazolones III. Compounds II on treatment with one molar quantity of thiocarbohydrazide (TCH) yielded 4-(substituted phenyl) azo-5-methyl-2- thiocarboxyhydrazino-3-pyrazolones IV whereas bis-2-[4-(substituted phenyl) azo-5-methyl-3-pyrazolone] thioketones V were obtained by treating II with two molar quantity of TCH. All the final desired compounds have been synthesized by microwave irradiation technique as well as classical thermal method. The structures of the newly synthesized compounds have been established by analytical and spectral methods.
- Dabholkar, Vijay V.,Hawaldar, Freddy,Khapare, Sachin
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experimental part
p. 249 - 252
(2011/12/15)
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- Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives
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Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent.
- Isloor, Arun M.,Kalluraya, Balakrishna,Sridhar Pai
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experimental part
p. 825 - 830
(2010/04/04)
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- 2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists
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A pharmacophore-based screen identified 32 compounds including ethyl 5-amino-3-(4-tert-butylphenyl)-4-oxo-3,4-dihydrothieno[3,4-d] pyridazine-1-carboxylate (8) as a new allosteric modulator of the adenosine A1 receptor (A1AR). On the basis of this lead, various derivatives were prepared and evaluated for activity at the human A 1AR. A number of the test compounds allosterically stabilized agonist-receptor-G protein ternary complexes in dissociation kinetic assays, but were found to be more potent as antagonists in subsequent functional assays of ERK1/2 phosphorylation. Additional experiments on the most potent antagonist, 13b, investigating A1AR-mediated [35S]GTPγS binding and [3H]CCPA equilibrium binding confirmed its antagonistic mode of action and also identified inverse agonism. This study has thus identified a new class of A1AR antagonists that can also recognize the receptor's allosteric site with lower potency.
- Ferguson, Gemma N.,Valant, Celine,Horne, James,Figler, Heidi,Flynn, Bernard L.,Linden, Joel,Chalmers, David K.,Sexton, Patrick M.,Christopoulos, Arthur,Scammells, Peter J.
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experimental part
p. 6165 - 6172
(2009/10/09)
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- Sydnones as masked hydrazines for the synthesis of 4-arylazo-1,2-dihydro- pyrazol-3-one derivatives
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A simple and convenient one-pot synthesis of 4-(4-chlorophenylazo)-5- methyl-2-aryl-1,2-dihydro-pyrazol-3-ones (4a-j) has been carried out from 3-arylsydnones (3a-j) by reaction with 2-(4-chlorophenyl)-hydrazono-3-oxo- butyric acid ethyl ester (2b). The 3-arylsydnones are used as masked hydrazines in this reaction. Similarly, the 4-arylazo-2-(7-hydroxy-4-methyl-2-oxo-2H- chromen-8-ylmethyl)-5-methyl-1,2-dihydro-pyrazol-3-ones (7a-j) were synthesized from 3-[(7-acetoxy-4-methyl-8-methylene)coumaryl]sydnone (5). All the newly synthesized compounds exhibited antimicrobial activity greater than the reference drugs used. Copyright Taylor & Francis, Inc.
- Shinge, Prashant S.,Latthe, Prashant R.,Badami, Bharati V.
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p. 2169 - 2176
(2007/10/03)
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- Pyrrole-condensed morphinoid derivatives
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A compound or a salt or solvate thereof, of formula (I): in which: R1 is hydrogen, alkenyl or alkyl; R2 is hydrogen or one or more alkyl groups; R5 is hydrogen or alkyl; Rx is hydrogen or alkyl; or Rx /sub
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Page/Page column 7
(2010/02/05)
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- Synthesis, characterization and electrochemical behaviour of some substituted 3-arylazo-8-aldehydo-4-methylcoumarins at dropping mercury and glassy carbon electrodes
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A series of 3-arylazo-8-aldehydo-4-methylcoumarins have been synthesized in excellent yields (80 - 90%) and their structures established on the basis of IR, 1H NMR and elemental analysis. Their purity has been ascertained by chromatographic resolution using acetic acid-toluene (6:4, v/v) as eluent. The electrochemical reduction of 3-arylazo-8-aldehydo-4-methylcoumarins have been studied over a wide pH range at dropping mercury and glassy carbon electrodes. All the compounds found to exhibit well-defined, diffusion-controlled irreversible wave. They give two-electron wave corresponding to the reduction of azo group. On the basis of cyclic voltammetry, coulometry, spectrophotometry, number of protons involved in the rate-determining step, the number of electrons in the reduction and product identification, a plausible reduction mechanism is suggested. Kinetic parameters, i.e. charge-transfer coefficient (αn) and forward rate constant (Kf,h) have also been calculated. The pK values are calculated by polarographic and spectrophotometric method.
- Kumar, Ashok,Sharma, Pratibha,Sharma, Ravi
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p. 363 - 368
(2007/10/03)
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- Synthesis of N′-(2-hydroxybenzoyl)-3-methyl-4-(substituted-phenylhydrazono)-2- pyrazolin-5-ones
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N′-(2-Hydroxybenzoyl)-3-methyl-4-(substituted-phenylhydrazono)-2- pyrazolin-5-ones have been synthesised by the reaction of 2-(substituted-phenylhydrazono)-ethyl-2,3-dioxobutyrate with salicylic acid hydrazine.
- Venkata Ramana,Ravindranath
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p. 112 - 113
(2007/10/03)
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- Effects of temperature on the polarographic behaviour of 3-methyl-(4'-substiotuted-benzeneazo)-2-isoxazolin-5-ones
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The polarographic behaviour of 3-methyl-4-(4'-substituted-benzeneazo)-2-isoxazolin-5-ones has been studied in 50 percent (v/v) dimethylfomamide solution in Britton-Robinson buffer of pH 4.1 at differnt temperatures (303.15-333.15 K). The reduction is found to be diffusion-controlled and irreversible at different temperatures. The shift of E1/2 values towards more negative potentials and decrease in the values of αna and kof,h suggest that the electrode reaction becomes more irreversible at elevated temperatures. The thermodynamic quantities have been evaluated.
- Ramana, P. Venkata,Ravindranath, L. K.
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- Porphyrins with Exocyclic Rings. 1. Chemistry of 4,5,6,7-Tetrahydro-1H-indoles: Synthesis of Acetoxy Derivatives, Dihydroindoles, and Novel Porphyrins with Four Exocyclic Rings
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A variety of 4,5,6,7-tetrahydro-1H-indoles (THI's) and 4-oxo-4,5,6,7-tetrahydro-1-indoles (4-oxoTHI's) have been synthesized from cyclohexanone and 1,3-cyclohexanedione, respectively.The THI's reacted regioselectively with lead tetraacetate in acetic acid
- Lash, Timothy D.,Bladel, Karla A.,Shiner, Craig M.,Zajeski, Donna L.,Balasubramaniam, Rajiv P.
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p. 4809 - 4820
(2007/10/02)
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- On the Polarographic Reduction Mechanism of Some Heterocyclic Compounds
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For evaluating the mechanistic steps, position at d.m.e. and assigning inner or outer sphere path of electrode processes of a number of pyrazole derivatives, thiazoles and their precursors experiments were carried out in the absence and presence of surfactants.All the compounds gave diffusion-controlled, irreversible waves over the entire pH range (2.0-11.0) studied.In presence of surfactants also, diffusion-controlled but more irreversible waves were obtained.In absence and presence of surfactant (CTAB) values of Kapp and αapp for all these compounds were calculated and have been taken as a proof of inner sphere or outer sphere path of the electrode reaction.Results have been explained on the basis of formation of phenylazo-functionalised surfactant as an intermediate species.
- Malik, Wahid U.,Jain, Rajeev
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p. 191 - 194
(2007/10/02)
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- Syntheses and antiinflammatory actions of 4,5,6,7-tetrahydroindazole-5-carboxylic acids.
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A novel series of 1-aryl-4,5,6,7-tetrahydro-1H-indazole-5-carboxylic acids and 2-aryl-4,5,6,7-tetrahydro-2H-indazole-5-carboxylic acids were synthesized via condensation between a phenylhydrazine and a 2-(hydroxymethylene)cyclohexanone-4-carboxylate, and
- Nagakura,Ota,Shimidzu,Kawamura,Eto,Wada
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