cas 104777-32-4, Ethanone, 2-bromo-1-(3-methyl-5-isoxazolyl)

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Synthesis and pharmacological characterization of new analogs of broxaterol
A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.
De Amici,Conti,Dallanoce,Kassi,Castellano,Stefancich,De Micheli
p. 69 - 80
(2007/10/03)

SUBSTITUTED SULFONAMIDES AS SELECTIVE BETA-3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.
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(2008/06/13)

N-(4-isoxazolylthiazol-2-yl)oxamic acid derivatives as potent orally active antianaphylactic agents
A series of N-(4-isoxazolylthiazol-2-yl)oxamic acid derivatives was synthesized and tested on the passive cutaneous anaphylaxis (PCA) model in rats to verify its potential antianaphylactic activity. These compounds were prepared by reaction of an appropri
Chiarino,Grancini,Frigeni,Biasini,Carenzi
p. 600 - 605
(2007/10/02)

Synthesis of New Isoxazole Aminoalcohols
The preparation of new 1-isoxazolyl-2-amino-1-ethanol derivatives is described starting from the corresponding 1-isoxazolylethanones.It is also reported the synthesis of 1-(5-isoxazolyloxy)-3-amino-2-propanol compounds starting from the corresponding 5-ha
Chiarino, D.,Fantucci, M.,Sala, A.,Veneziani, C.
p. 337 - 342
(2007/10/02)

Chemical Properties

Melting Point: 44-46 °C(Solv: isopropanol (67-63-0))
Boiling Point: 281.773 °C at 760 mmHg
Flash Point:124.212 °C
Density: 1.614 g/cm³
Vapor Pressure: 0.003mmHg at 25°C
Refractive Index: 1.533
PKA: -3.67±0.50(Predicted)
PSA: 43.10000
LogP: 1.56060

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Chemical Properties

Melting Point: 44-46 °C(Solv: isopropanol (67-63-0))

Boiling Point: 281.773 °C at 760 mmHg

Flash Point:124.212 °C

Density: 1.614 g/cm³

Vapor Pressure: 0.003mmHg at 25°C

Refractive Index: 1.533

PKA: -3.67±0.50(Predicted)

PSA: 43.10000

LogP: 1.56060

Global suppliers and manufacturers of 104777-32-4total 14 suppliers on LookChem

Article Database

104777-32-4

Articles about 104777-32-4Total 4 be found

More Articles about upstream products of 104777-32-4

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Chemical Properties

Melting Point: 44-46 °C(Solv: isopropanol (67-63-0))

Boiling Point: 281.773 °C at 760 mmHg

Flash Point:124.212 °C

Density: 1.614 g/cm3

Vapor Pressure: 0.003mmHg at 25°C

Refractive Index: 1.533

PKA: -3.67±0.50(Predicted)

PSA: 43.10000

LogP: 1.56060

Global suppliers and manufacturers of 104777-32-4total 14 suppliers on LookChem

Density: 1.614 g/cm³