Control by one drop of solvent: Selective preparation of guest release/trap-triggered interconvertible molecular crystals
Interconvertible molecular crystals 1close and 1open composed of 4-pyridyl-1,3-indanedione dimer 1 were selectively obtained. Thermal removal of solvent molecules in 1open afforded 1close. Further dipping of 1close in a specific solvent reproduced 1open. No crystallinity loss was observed even though both processes involved a drastic change of molecular packing arrangements.
Thermal cyclization of 3-azido-2-phenyl-indan-1-one to 5H-indeno[1,2-b]indol-10-one [1]
3-Azido-2-phenylindan-1-one (4), which was obtained from 3-chloro-2-phenylindan-1-one (3), cyclizes on thermolysis to 5H-indeno[1,2-b]indol-10-one (5). Reaction of 3-azido-2-phenylindan-1-one (4) with triphenylphosphane gives 2-phenyl-3-(triphenylphosphoranylideneamino)-indan-1-one (6), which can be hydrolyzed to 3-amino-2-phenylindan-1-one (7). Attempts to perform a similar cyclization sequence with 3-chloro-2-pyridylindan-1-ones failed.
2-Methylene-1,3-indanediones: Azaaromatic anticoagulants without enolizable carbonyl functions
The anticoagulant activities of five 2-methylene- and two 2-oxaspiro-indanediones show that the enolizability of the carbonyl functions is no structural essential in anticoagulants. The spiro compounds exhibit prolonged activities.
Rehse,Brandt
p. 54 - 58
(2007/10/02)
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