cas 104857-48-9, 4-(2-Oxiranylmethoxy)-benzeneethanol

Articles about 104857-48-9Total 6 be found

EPOXY-(METH)ACRYLATE MONOMERS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME
The present invention relates to the unexpected discovery of novel monomer compounds capable of crosslinking interpenetrating polymer networks (IPNs). In certain embodiments, the monomer compounds of the invention each comprise at least one methacrylate f
-
Paragraph 0172-0174

(2020/02/27)

Preparation method and application of 1-[(4-hydroxyethyl) phenoxy]-3-(isopropylamino) propan-2-ol
The invention belongs to the technical field of medicine preparation, and mainly relates to a preparation method of a compound 1-[(4-hydroxyethyl) phenoxy]-3-(isopropylamino) propyl-2-ol and application of the compound in betalol hydrochloride and betalol
-
Paragraph 0019-0021

(2020/10/04)

Chemoenzymatic route to S-betaxolol
An efficient chemoenzymatic route to S-betaxolol is reported. A strain (Rhodotorula mucilaginosa DQ832198) screened from soil was used as biocatalyst for the kinetic resolution of the key acetylated intermediates. Excellent enantiomeric excess (ee99%) was
Li, Yong-Hong,Huang, Li-Hua,Liu, Hong-Min
scheme or table
p. 2468 - 2474
(2011/08/05)

Non-enzymatic kinetic resolution of β-amino alcohols using C-12 higher carbon sugar as a chiral auxiliary
An efficient non-enzymatic kinetic resolution strategy capable of accessing optically active β-adrenergic antagonists intermediates is reported. The C-12 higher carbon sugar derived from naturally occurring sucrose was employed to probe the kinetic resolution. Excellent enantiomeric excesses (ee >99%) and high yields were obtained under very mild conditions. The chiral auxiliary could be recovered in a high reclaimed ratio (>95%) and reusable form without any decrease of the resolving ability.
Zhang, Jing-Yu,Liu, Hong-Min,Xu, Hai-Wei,Shan, Li-Hong
p. 512 - 517
(2008/09/19)

Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution
Enantiopure (S)-metoprolol and (S)-betaxolol were prepared in an extremely simple and practical way using Jacobsen's hydrolytic kinetic resolution of terminal epoxides in isopropanol.
Muthukrishnan,Garud, Dinesh R.,Joshi,Joshi
p. 1872 - 1876
(2007/10/03)

Process for preparing substituted phenol ethers via oxazolidine-structure intermediates
Phenol ethers such as 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol, otherwise known as betaxolol, of formula: STR1 are prepared from p-hydroxyphenethyl alcohol by first reacting at the phenolic group, with epichlorohydrin followed by isopropylamine, to prepare the required secondary amine-hydroxy side chain. Protection of the alcoholic group is not required during these steps. Then the secondary amine-alcohol group is protected by reaction with a suitable aldehyde such as benzaldehyde to form an oxazolidine ring protectant while the alcohol chain is elaborated. The oxazolidine ring protectant is removed by simple acid hydrolysis.
-
(2008/06/13)