CYCLIZATION OF NITRILES. XVIII. SYNTHESIS AND SOME TRANSFORMATIONS OF 6-ARYL-4-TRIFLUOROMETHYL-3-CYANO-2(1H)-PYRIDINETHIONES
The reaction of 3-benzoyl- and 3-(2-thenoyl)-1,1,1-trifluoroacetone and also of 1-benzoyl- and 1-(2-thenoyl)-2-(1-morpholino)-3,3,3-trifluoro-1-propenes with cyanothioacetamide provides a convenient method for the production of 6-phenyl- and 6-(2-thienyl)-4-trifluoromethyl-3-cyano-2(1H)-pyridine thiones, which are used in the synthesis of substituted 3-aminothienopyridines and other condensed heterocyclic systems.
Rodinovskaya, L. A.,Sharanin, Yu. A.,Litvinov, V. P.,Shestopalov, A. M.,Promonenkov, V. K.,et al.
p. 2230 - 2235
(2007/10/02)
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