- Cis versus Trans: The Coordination Environment about the Tin(IV) Atom in Spirocyclic Amino Alcohol Derivatives
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The syntheses of amino alcohols MeN(CH2CH2CMe2OH)2 (1), MeN(CMe2CH2OH)(CH2CMe2OH) (2), MeN(CH2CH2CH2OH)(CH2CMe2OH) (3), MeN(CH2CH2CMe2OH)(CH2CMe2OH) (4), MeN(CH2CH2CMe2OH)(CH2CH2OH) (5), and MeN(CH2CH2OH) (CH2CH2CH2OH) (6) as well as spirocyclic tin(IV) alkoxides spiro-[nBuN(CH2CMe2O)2]2Sn (7), spiro-[MeN(CH2CH2CMe2O)2]2Sn (8), spiro-[para-FC6H4N (CH2CMe2O)2]2Sn (9), spiro-[MeN(CMe2CH2O)(CH2CMe2O)]2Sn (10), spiro-[MeN(CH2CH2CH2O)(CH2CMe2O)]2Sn (11), spiro-[MeN(CH2CH2CMe2O)(CH2CMe2O)]2Sn (12), spiro-[MeN(CH2CH2CMe2O)(CH2CH2O)]2Sn (13) and spiro-[MeN(CH2CH2O)(CH2CH2CH2O)]2Sn (14) are reported. The compounds were characterized by 1H, 13C (1–14) and 119Sn (7–14) NMR and IR spectroscopy, EIMS and single-crystal XRD (2, 7–10 and 13, 14). Graph-set analyses were performed for compounds [(MeNH(CMe2CH2OH)(CH2CMe2OH)][HC(O)O] (2 a) and 2. The coordination environment about the tin(IV) centre of the spirocyclic compounds and their possible stereoisomers were analysed by DFT calculations (spiro-[MeN(CH2CMe2O)2]2Sn, 8–10 and 13).
- Glowacki, Britta,Pallach, Roman,Lutter, Michael,Roesler, Fabian,Alnasr, Hazem,Thomas, Cedreric,Schollmeyer, Dieter,Jurkschat, Klaus
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- ACRIDIN-9-YL-AMINE, QUINOLIN-9-YL-AMINE, 1 -AMINO-9H-THIOXANTHENE-9-ONE AND BENZO[B][1,5]NAPHTHYRI DIN-10-YL-AMINE DERIVATIVES AS AUTOPHAGY INHIBITORS FOR TREATING CANCER
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This disclosure provides a cridin-9-yl-amine, quinolin-9-yl-amine, 1- amino-9H-thioxanthene-9-one and benzo[b][l,5]naphthyridin-10- yl-amine derivatives and structurally related compounds for use as autophagy inhibitors for treating cancer. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 77 to 155; examples 1 to 22; compound A; compounds 1 to 21; tables 1 to 3).
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Paragraph 0307
(2021/07/17)
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- AMINOALYL-IMIDAZOTETRAZINES FOR TREATMENT OF CANCER
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The present invention relates to imidazotetrazines of Formula (I) and their use in the treatment of cancer.
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Page/Page column 38-39
(2009/12/02)
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- Synthesis and structural characterization of zirconium complexes containing aminodiolate ligands and their use as Lewis acid catalysts
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A series of aminodiols RN(CH2CH2C(OH)R′2)2 (R, R′ = Me, Me 4; Me, Ph 5; tert-butyl, Me 6; tert-Bu, Ph 7; (S)-PhCH(Me), Me 8) were prepared by the Michael addition of a primary amine to methyl acrylate followed by reaction of the resulting aminodiester with excess methyl or phenyl lithium. Reaction of two equivalents of the aminodiols 4-8 with tetrabenzylzirconium afforded the zirconium bis(aminodiolates) 10-14 in excellent yield. Complex 11 (R, R′ = Me, Ph) adopts a cis, fac-octahedral geometry in solution and in the solid state. Complexes 10-14 are fluxional in solution by NMR spectroscopy: small substituents at nitrogen and large substituents at the alkoxide carbons slow the rate of exchange. The chiral complex 14 functions as a Lewis acid catalyst in the nitroaldol (Henry) reaction and the oxidation of geraniol by tert-butyl hydroperoxide with modest enantioselectivities (30 and 46% enantiomeric excess (ee), respectively).
- Shao, Pengcheng,Gendron, Roland A.L.,Berg, David J.
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p. 255 - 264
(2007/10/03)
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