- Grafting of oligoaniline on CdSe nanocrystals: Spectroscopic, electrochemical and spectroelectrochemical properties of the resulting organic/inorganic hybrid
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We have synthesised a new organic/inorganic hybrid, in which electroactive aniline tetramer is grafted on the surface of quasi-monodispersed CdSe nanocrystals. The grafting reaction consists of two steps. First initial nanocrystal surface ligands (TOPO) a
- Querner, Claudia,Reiss, Peter,Zagorska, Malgorzata,Renault, Olivier,Payerne, Renaud,Genoud, Francoise,Rannou, Patrice,Pron, Adam
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- Synthesis and Properties of Acridine and Acridinium Dye Functionalized Bis(terpyridine) Ruthenium(II) Complexes
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We present first principle studies on the rational design of an acridine/N-methylacridinium dye (Acr/MeAcr+) substituted terpyridine ligand to investigate if these chromophores can act as triplet-energy storage units in bis(terpyridine) ruthenium(II) complexes. We studied the influence of the dye form (Acr/MeAcr+) as well as the interconnecting linker unit (none, 4-phenyl, or 5-thien-2-yl) and investigated these aspects by steady-state/time-resolved spectroscopy, cyclic voltammetry, X-ray structure analysis, and DFT calculations.
- Eberhard, Jens,Peuntinger, Katrin,Fr?hlich, Roland,Guldi, Dirk M.,Mattay, Jochen
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- Visible-light-induced acetalization of aldehydes with alcohols
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In this work, we have achieved a simple and general method for acetalization of aldehydes by means of a photochemical reaction under low-energy visible light irradiation. A broad range of aromatic, heteroaromatic, and aliphatic aldehydes have been protected under neutral conditions in good to excellent yields using a catalytic amount of Eosin Y as the photocatalyst. Our visible light mediated acetalization strategies are successful for more challenging acid-sensitive aldehydes and sterically hindered aldehydes. Notably, this protocol is chemoselective to aldehydes, while ketones remain intact.
- Yi, Hong,Niu, Linbin,Wang, Shengchun,Liu, Tianyi,Singh, Atul K.,Lei, Aiwen
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supporting information
p. 122 - 125
(2017/11/27)
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- Porphyrin Boxes: Rationally Designed Porous Organic Cages
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The porphyrin boxes (PB-1 and PB-2), which are rationally designed porous organic cages with a large cavity using well-defined and rigid 3-connected triangular and 4-connected square shaped building units are reported. PB-1 has a cavity as large as 1.95 n
- Hong, Soonsang,Rohman, Md. Rumum,Jia, Jiangtao,Kim, Youngkook,Moon, Dohyun,Kim, Yonghwi,Ko, Young Ho,Lee, Eunsung,Kim, Kimoon
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supporting information
p. 13241 - 13244
(2015/11/09)
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- Synthesis of 1,5-substituted anthracenes by means of Kumada coupling and their derivatization
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Herein, we present a method to access a series of 1,5-functionalized anthracenes through Kumada coupling. All syntheses start from readily available 1,5-dichloroanthracene. The so-formed anthracenes are further derivatized to enable, for example, attachme
- Bringmann, Sebastian,Ahmed, Saleh A.,Hartmann, Ramona,Mattay, Jochen
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experimental part
p. 2291 - 2296
(2011/09/14)
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- USES OF KINASE INHIBITORS AND COMPOSITIONS THEREOF
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The invention pertains to inhibitors of various kinases (e.g. S/T kinases, Tyr kinases, etc.), which inhibitors are previously known as cyclin dependent kinase inhibitors (CDKs). As described herein, the inhibitors of this invention are capable of inhibit
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Page/Page column 93-94
(2008/06/13)
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- Chelating ligands for nanocrystals' surface functionalization
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A new family of ligands for the surface functionalization of CdSe nanocrystals is proposed, namely alkyl or aryl derivatives of carbodithioic acids (R-C(S)SH). The main advantages of these new ligands are as follows: they nearly quantitatively exchange th
- Querner, Claudia,Reiss, Peter,Bleuse, Joel,Pron, Adam
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p. 11574 - 11582
(2007/10/03)
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- INHIBITORS OF CYCLIN-DEPENDENT KINASES, COMPOSITIONS AND USES RELATED THERETO
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The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machiner
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- Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
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The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.
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- Process for the preparation of aryl-pyridinyl compounds
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A process is described for the preparation of arylpyridine compounds by aryl-aryl cross-coupling reactions between a halopyridine and an arylmagnesium halide carried out in the presence of a catalytic amount of a zinc salt and a catalytic amount of palladium. The zinc salt is preferably selected from ZnCl2, ZnBr2 and/or Zn(OAc)2, while the palladium is preferably used in the form of Pd(PPh3)4 or Pd(OAc)2 +4 PPh3. The reaction can also be carried out in the presence of bidentate phosphines, such as, for example, 1,3-bis(diphenylphosphine)propane or 1,4-bis(diphenylphosphine)-butane. It is thus possible to obtain molar yields higher than 97% (calculated relative to the halopyridine) and a catalyticity of more than 2000.
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Page column 8-9
(2010/02/07)
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- Synthesis of a linear bis-porphyrin with a Ru(phen)22+-complexed 2,2′-bipyridine spacer
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A linear bis-porphyrin bridged by a 5,5′-diphenyl-2,2′-bipyridine rod-like spacer complexing a [Ru(phen)2]2+ fragment has been synthesized in 7.4% yield by one-pot condensation of 3,5-di-tert-butylbenzaldehyde, 4,4′-dimethyl-3,3′-dihexyl-2,2′-methylenedipyrrole and the [Ru(phen)2]2+ complex of 5,5′-bis(p-formylphenyl)-2,2′-bipyridine, followed by chloranil oxidation. The protected dialdehyde (5,5′-bis[(5,5-dimethyl-1,3-dioxan-2-yl)phenyl]-2,2′-bipyridine) was obtained in 80% yield by Suzuki coupling of 2-[4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl]-4,4,5,5-tetramethyl-1, 3-dioxaborolane and 5,5′-dibromo-2,2′-bipyridine, using [Pd(PPh3)4] as catalyst. A new procedure is reported for the preparation of 5,5′-dibromo-2,2′-bipyridine, which is obtained in 80% yield by Stille homocoupling of 2,5-dibromopyridine in the presence of hexamethylditin.
- Bruce, James I.,Chambron, Jean-Claude,Koelle, Philipp,Sauvage, Jean-Pierre
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p. 1226 - 1231
(2007/10/03)
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- Synthesis of "Porphyrin-Linker-Thiol" Molecules with Diverse Linkers for Studies of Molecular-Based Information Storage
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The attachment of redox-active molecules such as porphyrins to an electroactive surface provides an attractive approach for electrically addressable molecular-based information storage. Porphyrins are readily attached to a gold surface via thiol linkers. The rate of electron transfer between the electroactive surface and the porphyrin is one of the key factors that dictates suitability for molecular-based memory storage. This rate depends on the type and length of the linker connecting the thiol unit to the porphyrin. We have developed different routes for the preparation of thiol-derivatized porphyrins with eight different linkers. Two sets of linkers explore the effects of linker length and conjugation, with one set comprising phenylethyne units and one set comprising alkyl units. One electron-deficient linker has four fluorine atoms attached directly to a thiophenyl unit. To facilitate the synthesis of the porphyrins, convenient routes have been developed to a wide range of aldehydes possessing a protected S-acetylthio group. An efficient synthesis of 1-(S-acetylthio)-4-iodobenzene also has been developed. A set of porphyrins, each bearing one S-acetyl-derivatized linker at one meso position and mesityl moieties at the three remaining meso positions, has been synthesized. Altogether seven new aldehydes, eight free base porphyrins and eight zinc porphyrins have been prepared. The zinc porphyrins bearing the different linkers all form self-assembled monolayers (SAMs) on gold via in situ cleavage of the S-acetyl protecting group. The SAM of each porphyrin is electrochemically robust and exhibits two reversible oxidation waves.
- Gryko, Daniel T.,Clausen, Christian,Roth, Kristian M.,Dontha, Narasaiah,Bocian, David F.,Kuhr, Werner G.,Lindsey, Jonathan S.
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p. 7345 - 7355
(2007/10/03)
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- Fullerene - Oligophenylenevinylene hybrids: Synthesis, electronic properties, and incorporation in photovoltaic devices
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Fullerene derivatives in which an oligophenylenevinylene (OPV) group is attached to C60 through a pyrrolidine ring have been prepared by 1,3-dipolar cycloaddition of the azomethine ylides generated in situ from the corresponding aldehydes and s
- Eckert, Jean-Francois,Nicoud, Jean-Francois,Nierengarten, Jean-Francois,Liu, Sheng-Gao,Echegoyen, Luis,Barigelletti, Francesco,Armaroli, Nicola,Ouali, Lahoussine,Krasnikov, Victor,Hadziioannou, Georges
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p. 7467 - 7479
(2007/10/03)
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- Synthesis of a C60-oligophenylenevinylene hybrid and its incorporation in a photovoltaic device
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A fullefopyrrolidine derivative bearing an oligophenylenevinylene substituent has been prepared by 1,3-dipolar cycloaddition of an azomethine ylide to C60 and incorporated in a photovoltaic device.
- Nierengarten, Jean-Francois,Eckert, Jean-Francois,Nicoud, Jean-Francois,Ouali, Lahoussine,Krasnikov, Victor,Hadziioannou, Georges
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p. 617 - 618
(2007/10/03)
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- 11 β-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
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13-alkyl-11β-phenyl-gonanes of general formula I STR1 wherein A and B together stand for an oxygen atom, a CH2 group or a second bond between carbon atoms 9 and 10, X is an oxygen atom or the hydroxyimino grouping N?OH, R1 is a straight-chained or branched, saturated or unsaturated alkyl radical with up to 8 carbon atoms, which contains the grouping STR2 with X as described above, R2 is a methyl or ethyl radical in the α or β position, R9, R10, R11 and R12 each stand for a hydrogen atom, a hydroxy, alkyl, alkoxy or acyloxy group with 1 to 4 carbon atoms respectively or a halogen atom and R3 and R4 have a variety of meanings, have antigestagenic and antiglucocorticoid effects.
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- Exploratory Routes to Carbazole Derivatives Prelusive to 6H-Pyridocarbazole synthesis.
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Synthetic approaches to 3-acyl substituted carbazoles are explored.Diels-Alder additions of 2-methyl-3-trimethylsilyloxybuta-1,3-diene (7) with crotononitrile or methyl vinyl ketone gave stereoisomeric 5-cyano (or acetyl) 1-methyl-2-trimethylsilyloxy-cyclohex-1-enes.The former were readily hydrolysed to the corresponding cyclohexanones which failed to undergo Borsche cyclisation under the conditions used.The latter were reduced and then hydrolysed to a stereoisomeric mixture of 4-(1-hydroxyethyl)-2-methyl- cyclohexanones (14).The Borsche cyclisation of (14) with phenylhydrazine was attempted under a wide variety of conditions followed by attempted dehydrogenation of the intermediate tetrahydrocarbazoles with chloranil, but loss of the hydroxyethyl side chain took place giving 1-methylcarbazole as the sole isolable carbazole.In the second approach a number of N-acyl substituted diphenylamines are synthesised by the Goldberg reaction.Those lacking a 4-substituent undergo a photo-anilide rearrangement which is accompanied by carbazole formation.Diphenylamides with a 4- substituent, after hydrolysis to the diphenylamines, undergo photochemical cyclisation to 3- carbazoles but in low yield.The Goldberg synthesis of 4-formyldiphenylamides affords substantial amounts of the 4-formyldiphenylamines after work-up.These, on reaction with palladium(II) acetate in acetic acid give a mixture of products including the required 3-formyl (or carboxyl) carbazoles.
- Hewlins, Michael J. E.,Jackson, Anthony H.,Long, Anthony,Oliveira-Campos, Ana,Shannon, Patrick V. R.
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p. 2645 - 2696
(2007/10/02)
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