- Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of α-Ketoesters: Synthesis of (S)-Flutriafol
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An enantioselective addition of arylboronic acids and α-ketoesters promoted by a Rhodium(I)-chiral diene catalyst is reported. The transformation proceeds regioselectively in the presence of as low as 0.5 mol% of the catalyst generated in situ from a Rhod
- Chang, Chiung-An,Uang, Tsung-Ying,Jian, Jia-Hong,Zhou, Meng-Yi,Chen, Ming-Liang,Kuo, Ting-Shen,Wu, Ping-Yu,Wu, Hsyueh-Liang
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p. 3381 - 3390
(2018/08/06)
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- Stereoselective synthesis of (+)-flutriafol
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The stereoselective synthesis of (+)-flutriafol, a triazole fungicide, has been accomplished in seven linear steps from (1S)-[(4R)-2,2-dimethyl-[1,3]-dioxolan-4-yl]-(4-methoxyphenyl)methanol in 15% overall yield. Diastereoselective nucleophilic 1,2-addition was employed as a key step for constructing the requisite chiral 1,2-diol for flutriafol. A high degree of 1,4-asymmetric induction could be realized via a chelation-controlled mechanism during the key alkylation step.
- Chang, Minsun,Kim, Tae Hyun,Kim, Hee-Doo
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p. 1503 - 1507
(2008/12/21)
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