- Synthesis of Citrus polymethoxyflavonoids and their antiproliferative activities on Hela cells
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Abstract: A series of polymethoxyflavonoids (3–16) were synthesized through dehydrogenation, O-methylation, glycoside hydrolysis, bromination, microwave-assisted aromatic nucleophilic substitution, dimethyldioxirane oxidation and regioselective demethylation, starting from abundant and inexpensive natural sources naringin and hesperidin. All the synthetic compounds were test for antiproliferative activities on human cervical carcinoma Hela cell line by the standard CCK-8 assay, the result showed that most of the target compounds exhibited moderate to potent antiproliferative activities on Hela cells comparable with the positive control cis-Platin. Among them, 5-hydroxypolymethoxy flavonoid 13 showed the strongest activity (IC50 0.791 μM). Graphical Abstract: [InlineMediaObject not available: see fulltext.].
- Nguyen, Van-Son,Li, Wei,Li, Yue,Wang, Qiuan
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p. 1585 - 1592
(2017/06/05)
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- Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs
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Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.
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Page/Page column 48; 49; 50; 51
(2017/07/01)
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- USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS
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Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.
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Paragraph 0223; 0230
(2015/07/22)
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- Gastroprotective flavone/flavanone compounds with therapeutic effect on inflammatory bowel disease
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PCT No. PCT/KR97/00144 Sec. 371 Date Jan. 14, 1999 Sec. 102(e) Date Jan. 14, 1999 PCT Filed Jul. 25, 1997 PCT Pub. No. WO98/04541 PCT Pub. Date Feb. 5, 1998The present invention relates to novel flavone/flavanone compounds or their pharmaceutically acceptable salts and process for preparation thereof for protecting gastrointestinal tracts against gastritis, ulcers and inflammatory bowel disease.
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- On a Thermal Transmethylation Reaction with Flavon-5-methylethers
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Upon heating to 300 deg C partial luteolinemethylethers undergo transmethylation.A reaction mechanism is put foreward. - Key words: Flavonemethylethers, Thermal Transmethylation, TLC, HPLC, Reaction Mechanism
- Geiger, Hans,Casteele, Karel Vande,Sumere, Christiaan F. Van
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p. 393 - 396
(2007/10/02)
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- CHRYSOERIOL 7-(2''-O-β-D-ALLOPYRANOSYL)-β-D-GLUCOPYRANOSIDE FROM SIDERITIS GRANDIFLORA
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The aerial parts of Sideritis grandiflora yielded a new flavone glycoside, identified as chrysoeriol 7-(2''-allosylglucoside).Key Word Index - Sideritis grandiflora; Labiatae; 13C-NMR; chrysoeriol 7-(2''-O-β-D-allopyranosyl-β-D-glucopyranoside)
- Rabanal, Rosa M.,Valverde, S.,Martin-Lomas, M.,Rodriguez, B.,Chari, V. M.
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p. 1830 - 1832
(2007/10/02)
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