- A substituted including monofluoro-benzene [...] preparation method of the compound (by machine translation)
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The invention discloses a including monofluoro-benzene substituted [...] compound N - ((3 - (2 - fluoro - 5 - methoxyphenyl) - 1, 2, 4 - oxadiazole - 5 - yl) methyl) aminoethane preparation method, in order to 4 - fluoro anisole as the starting material,
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Paragraph 0025; 0026
(2018/03/24)
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- A preparation method of the compound [...] benzene substitution (by machine translation)
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The invention discloses a benzene substitution [...] compound N - ((3 - (2 - fluoro - 5 - methoxyphenyl) - 1, 2, 4 - oxadiazole - 5 - yl) methyl) aminoethane preparation method, in order to 4 - fluoro anisole as the starting material, through the aldehyde
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Paragraph 0024; 0025; 0026
(2018/03/26)
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- Synthesis method of fluorobenzene substituted oxadiazole compound
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The invention discloses a synthesis method of a fluorobenzene substituted oxadiazole compound N-((3-(2-fluoro-5-methoxyphenyl)-1,2,4-oxadiazole-5-yl)methyl)ethylamine. A target product 7 is obtained through hydroformylation, oximation, elimination, additi
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Paragraph 0024-0026
(2018/07/06)
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- GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
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Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula II.
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Page/Page column 83
(2017/03/17)
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- GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
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Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I), as follows: wherein R1, R2, R4, W, X, Y, and G, are defined herein.
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Page/Page column 98
(2017/03/08)
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- GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
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Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (III); wherein R1c, R2C, R4C, Wc, Yc, Zc and Gc, are defined herein.
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Page/Page column 94
(2017/03/08)
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- Synthesis of high-specific-radioactivity 4- and 6-[18F]fluorometaraminol- PET tracers for the adrenergic nervous system of the heart
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Fluorine-18 (t12:109.8min)-labeled analogues of metaraminol, 4-[18F]FMR ((1R,2S)-2-amino-1-(4-[18F]fluoro-3-hydroxy phenyl)-1-propanol) and 6-[18F]FMR ((1R,2S)-2-amino-1-(2-[18F]fluoro-5-hydroxyphenyl)-1-propanol), were synthesized as new positron-emission-tomography (PET) tracers for mapping cardiac adrenergic nerve terminals. Copyright
- Langer, Oliver,Dollé, Frédéric,Valette, Héric,Halldin, Christer,Vaufrey, Fran?oise,Fuseau, Chantal,Coulon, Christine,Ottaviani, Michéle,N?gren, Kjell,Bottlaender, Michel,Maziére, Bernard,Crouzel, Christian
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p. 677 - 694
(2007/10/03)
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- No-carrier-added asymmetric synthesis of α-methyl-α-amino acids labelled with fluorine-18
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Various [18F]fluoro aromatic α-methyl-L-amino acids T1 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential inhibitors of enzymatic functions, were regi
- Damhaut, Philippe,Lemaire, Christian,Plenevaux, Alain,Brihaye, Claude,Christiaens, Leon,Comar, Dominique
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p. 5785 - 5796
(2007/10/03)
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- Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of platinum(II) complexes
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The synthesis and structural characterization of mammary tumor-inhibiting, diastereomeric platinum(II) complexes with 2,6-Cl2, 2F, 6-Cl, 2-Cl, 6-F and 2,6-F2 substituents (1-PtSO4 to 4-PtSO4) are describ
- Gust, R,Schoenenberger, H
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p. 103 - 115
(2007/10/02)
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- Fluorine as an ortho-directing group in aromatic metalation: A two step preparation of substituted benzo[b] thiophene-2-carboxylates
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A simple 2-step synthesis of B-ring substituted benzo[b]thiophene-2-carboxylates from aryl fluorides has been developed. The route involves a selective lithiation ortho to fluorine, followed by formylation, and subsequently, displacement of fluorine with
- Bridges, Alexander J.,Lee, Arthur,Maduakor, Emmanuel C.,Eric Schwartz
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p. 7499 - 7502
(2007/10/02)
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- Unexpected Regioselectivity in the Lithiation of Fluoroanisoles
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The regioselectivity of lithiation of a series of fluoroanisoles and fluoroveratroles has been studied by determining the ratio of isomeric aldehydes produced by dimethylformamide quenching.The position of lithiation is influenced by such factors as temperature and time of the reaction.Contrary to published reports, fluorine competes significantly with the methoxy group as an ortho director in lithiation reactions.Lithiation of dimethyl-tert-butylsilyl ethers of fluorophenols proceeds exclusively ortho to fluorine.
- Furlano, David C.,Calderon, Silvia N.,Chen, George,Kirk, Kenneth L.
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p. 3145 - 3147
(2007/10/02)
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- tert-BUTYLDIMETHYLSILYL ETHERS OF PHENOLS: THEIR ONE-STEP CONVERSION TO BENZYL OR METHYL ETHERS AND UTILITY IN REGIOSELECTIVE ortho LITHIATION
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A new method for the one-step conversion of tert-butyldimethylsilyl ethers of phenols to benzyl or methyl ethers and the blocking effect of the tert-butyldimethylsilyloxy group in regioselective ortho lithiation are described.
- Sinhababu, Achintya K.,Kawase, Masami,Borchardt, Ronald T.
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p. 4139 - 4142
(2007/10/02)
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- Steric Effects on Atropisomerism in Tetraarylporphyrins
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The rate of aryl ring rotation in a series of 5,10,15,20-tetrakis(2-X-5-methoxyphenyl)porphyrins, where X = H, F, Cl, Br, and I, was studied by NMR spectroscopy and chromatography.Where X = Cl, Br, and I, the four atropisomers αβαβ, ααββ, αααβ, and αααα w
- Crossley, Maxwell J.,Field, Leslie D.,Forster, Adrienne J.,Harding, Margaret M.,Sternhell, Sever
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p. 341 - 348
(2007/10/02)
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