- Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents
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A lead compound A was identified previously as an stearoyl coenzyme A desaturase (SCD) inhibitor during research on potential treatments for obesity. This compound showed high SCD1 binding affinity, but a poor pharmacokinetic (PK) profile and limited chem
- Imamura, Keisuke,Tomita, Naoki,Kawakita, Youichi,Ito, Yoshiteru,Ono, Kouji,Nii, Noriyuki,Miyazaki, Tohru,Yonemori, Kazuko,Tawada, Michiko,Sumi, Hiroyuki,Satoh, Yoshihiko,Yamamoto, Yukiko,Miyahisa, Ikuo,Sasaki, Masako,Satomi, Yoshinori,Hirayama, Megumi,Nishigaki, Ryuichi,Maezaki, Hironobu
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- PHARMACEUTICAL COMPOUNDS
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The invention provides compounds of the formula (I): or salts, solvates, tautomers or N-oxides thereof, wherein J1-J2 is CH=CH, N=CH, CH=N, HN-C(O) or CH2CO; T is N or CH and GP is as defined in the claims. The compounds have activity as inhibitors of PKA and PKB kinases and are useful in the treatment of cancers.
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Page/Page column 98-99
(2008/06/13)
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