Manufacture of 1-disubstituted aminoalk-2-yn-4-ols
The manufacture of N-disubstituted 1-aminoalk-2-yn-4-ols by reacting a secondary amine, e.g. a dialkylamine, formaldehyde and an acetylene-alcohol by a Mannich reaction, using a copper catalyst, takes place with better yield and at a higher rate if carried out in the presence of iodine or of a bromide or iodide.
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(2008/06/13)
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