Theoretical studies, synthesis, and biological activity of 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4- carbonitrile (C9) as a non-peptide antagonist of the arginine vasopressin V1a and V2 receptors
In this work, the synthesis of 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5- tetrahydro-1H-1-benzazepine-4-carbonitrile (C9) and the study of its biological activity as a new putative antagonist of vasopressin receptors are described. The chemical identific
Contreras-Romo, M. Citlalli,Correa-Basurto, Jose,Padilla-Martinez, Itzia,Martinez-Archundia, Marlet,Martinez-Ramos, Federico,Slusarz, Magdalena J.,Lopez-Perez, Gilberto,Quintanar-Stephano, Andres
p. 1581 - 1590
(2014/03/21)
POLYCYCLIC N-HETERO COMPOUNDS. XXI. SYNTHESIS OF NOVEL RING SYSTEM, 4H-IMIDAZOPYRIMIDOBENZAZEPINE AS B-HOMO-6,11,13,15-TETRAAZASTEROIDAL ANALOGRUE
A synthesis of 4Hh-imidazopyrimido1>benzazepine (XIIIa) having a novel ring system is described.Methyl anthranilate (IVa) was converted to 4-(2-hydroxylethylamino)-6,7-dihydro-5H-pyrimidobenzazepine (XIIXa) in several steps and XIa was cyclized to XIIIa.A synthesis of 8-chloro derivatives of XIIIa is also described.