- Practical method for parallel synthesis of diversely substituted 1-phenylpiperazines
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A simple and practical method to prepare 'libraries' of substituted 1-phenylpiperazine building blocks in parallel format has been developed.
- Konstantinova, Igor,Bukhryakov, Konstantin,Gezentsvey, Yuri,Krasavin, Mikhail
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experimental part
p. 628 - 630
(2012/05/21)
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- Urea derivative useful as an anti-cancer agent and process for preparing same
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The present invention relates to a novel urea derivative represented by the following formula (I), which is useful as an anti-cancer agent: 1its pharmaceutically acceptable acid addition salt or stereoisomer, in which X, Y, B and Het have the meaning as
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- SYNTHESE DE N,N-DIALKYL-3,5-DIALKYL-ANILINES A PARTIR DES SELS DE TRIALKYL-2,4,6-PYRYLIUM
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We have optimized through an experimental design the synthesis of N,N-diethyl-3,5-dimethylaniline from 2,4,6-trimethylpyrylium terafluoroborate (I) and diethylamine in a new reaction medium (acetonitrile/triethylamine).Optimal conditions have been applied with high yields to the synthesis of various 3,5-dimethylanilines derived from I and dimethylamine, morpholine, N-methylpiperazine, piperazine, dihexylamine, piperidine, and pyrrolidine respectively. 2-Alkyl-4,6-dimethylpyrylium tetrafluoroborates react regioselectively with diethylamine to afford N,N-diethyl-3-alkyl-5-methyl anilines under these conditions.
- Vernaudon, Pascal,Rajoharison, Harivelo G.,Roussel, Chritian
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p. 205 - 211
(2007/10/02)
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