New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: Application of peptide coupling agents EDC and HBTU
Conversion of carboxylic acids into acid azides using peptide coupling agents, EDC and HBTU is described. The procedure is efficient, practical and applicable to a diverse range of carboxylic acids including N-protected amino acids. Using the same reagents, one-pot synthesis of ureas, dipeptidyl urea esters and carbamates from acids has also been achieved. The Royal Society of Chemistry 2010.
Microwave-assisted intramolecular cyclization of electron-rich heterocycle derivatives by a palladium-catalyzed coupling reaction
Nitrogenated heteropolycyclic systems were obtained by intramolecular palladium-catalyzed coupling reactions promoted by microwave irradiation. Georg Thieme Verlag Stuttgart.
Ethyl azidoformate is shown to attack a range of thiophenes at sulphur giving transient S,N-ylides which can be trapped with acenaphthylene as adducts; thiophene yields self-trapped products also.
Meth-Cohn, Otto,Vuuren, Gerda van
p. 1105 - 1108
(2007/10/02)
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