- Fatty acid polyoxyethylene sulfosuccinate sulfonate and its preparation and use
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The invention provides a fatty acid polyoxyethylene succinic acid ester sulfonate, which is characterized by having a structure shown in the specification. Specifically, n is an integer of 2-15, R is alkyl with a carbon atom number of 7-19, and M is Na or K. Compared with the prior art, the micro-cutting fluid made from the fatty acid polyoxyethylene succinic acid ester sulfonate provided by the invention has good lubricity and biodegradability, a small amount of the micro-cutting fluid can meet the high-end demands of metal processing, the harm to the environment and workers is reduced, and the environmental pollution can be minimized.
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Paragraph 0067
(2016/10/08)
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- Combinatorial synthesis of PEG oligomer libraries
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A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.
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Page/Page column 11
(2010/02/15)
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