- Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts
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Herein are reported ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages, including 2,4′-, 2,3′-, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes. The methodology was successfully applied to the synthesis of the natural products caerulomycin A and E.
- Horan, Alexandra M.,Duong, Vincent K.,McGarrigle, Eoghan M.
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supporting information
p. 9089 - 9093
(2021/11/30)
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- 2-Pyridyl and 3-pyridylzinc bromides: direct preparation and coupling reaction
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A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, respectively. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the corresponding cross-coupling products in moderate to good yields.
- Kim, Seung-Hoi,Rieke, Reuben D.
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scheme or table
p. 3135 - 3146
(2010/06/13)
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- A facile synthetic approach to the preparation of 3-pyridyl derivatives: Preparations and coupling reactions of 3-pyridylzinc and its analogues
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A facile synthetic approach to the direct preparation of 3pyridylzinc bromide has been demonstrated using Rieke zinc with 3-bromopyridine in the presence of a catalytic amount of lithium chloride. A variety of different electrophiles have been coupled to give the corresponding cross-coupling products in moderate to good yields. Also, this methodology has been expanded to the preparation of the corresponding organozinc reagents of 3-bromopyridine analogues. Georg Thieme Verlag Stuttgart.
- Kim, Seung-Hoi,Slocum, Tim B.,Rieke, Reuben D.
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experimental part
p. 3823 - 3827
(2010/03/04)
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- Palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters with aryl halides using highly active and air-stable phosphine chloride and oxide ligands
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(Chemical Equation Presented) The palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters provided an efficient approach to useful biaryl building blocks containing a 2-pyridyl moiety. The convenient reaction protocol demonstrates its pote
- Yang, David X.,Colletti, Steven L.,Wu, Kevin,Song, Maoying,Li, George Y.,Shen, Hong C.
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supporting information; experimental part
p. 381 - 384
(2009/07/11)
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- AMIDE DERIVATIVE
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The present invention provides an amide derivative represented by the following general formula (1): wherein R1 represents a saturated cyclic amino group, R2 represents alkyl, halogen or haloalkyl, R3 represents hydrogen or halogen, Het 2 represents pyridyl or pyrimidinyl, and Het 1 represents a group of the formula [6], or a salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.
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Page/Page column 22
(2008/06/13)
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- Cross-coupling between 3-pyridylmagnesium chlorides and heteroaromatic halides
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Phenyl- and thienylpyridines were prepared by Pd(0)-catalyzed cross-coupling of 3-pyridylmagnesium chlorides with iodobenzene or iodothiophene at room temperature. Starting from bromo and chloro azines and diazines, the Ni(0)-catalyzed reaction proved more suitable to allow the synthesis of pyridylpyridines, pyridylquinolines and pyridyldiazines.
- Bonnet, Véronique,Mongin, Florence,Trécourt, Fran?ois,Breton, Gilles,Marsais, Francis,Knochel, Paul,Quéguiner, Guy
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p. 1008 - 1010
(2007/10/03)
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