- Compound serving as NaV1.8 retardant as well as preparation method and application of compound
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The invention discloses a compound serving as a NaV1.8 retardant as well as a preparation method and application of the compound. Specifically, the invention discloses a compound shown as a formula (I) or pharmacologically acceptable salt thereof, and the compound has good NaV1.8 retarding activity and also has good pharmacokinetic activity; the formula is disclosed in the invention.
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- 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
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Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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