- The partial molar volume and heat capacity of the glycyl group in aqueous solution at 25°C
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The partial molar volumes, V°2, and the partial molar heat capacities, C°p,2, at infinite dilution have been determined for three new peptides of sequence seryl(glycyl)xglycine, where x=0 to 2, in aqueous solution at 25°C.
- Wise, Nessha M.,Hedwig, Gavin R.
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- THERAPEUTIC AGENT FOR PRURITUS
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The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus.
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- CELL DEATH INDUCING AGENTS
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The present inventors constructed a DNA expression vector encoding 2D7sc(Fv)2 in which the heavy chain variable region sequence (VH) and the light chain variable region sequence (VL) of the 2D7 antibody is arranged in the order of VH-VL-VH-VL, and these sequences are linked by a 15-mer linker. The vector was introduced into CHO cells and a 2D7sc(Fv)2-producing expression cell line was established. When 2D7sc(Fv)2 was expressed in this cell line, purified, and cell death-inducing experiments performed, 2D7sc(Fv)2 was found to have a concentration-dependent cell death-inducing activity.
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