Decarboxylative Olefination of Activated Aliphatic Acids Enabled by Dual Organophotoredox/Copper Catalysis
Herein, we demonstrate a dual organophotoredox/copper catalytic strategy toward challenging decarboxylative olefination processes proceeding in high yields and selectivities. This operationally simple method uses photoactive organic molecules and Cu(II)-complexes as catalysts to provide rapid access to a wide variety of olefins from inexpensive synthetic and biomass-derived carboxylic acids under mild light-mediated conditions. Mechanistic investigations suggest that the reaction rate for this process is controlled solely by the incident photon flux.
Tlahuext-Aca, Adrian,Candish, Lisa,Garza-Sanchez, R. Aleyda,Glorius, Frank
Synthesis and structure-opioid activity relationships of trans-(±)-3,4-Dichloro-N-methyl-N-[4- or 5-hydroxy-2-(1-pyrrolidiny)cyclohexyl]benzeneacetamides
To explore the effects of attaching a hydroxy function to the cyclohexane ring of κ-selective opioid N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamides trans-(±)-3,4-dichloro-N-methyl-N-[4- or 5-hydroxy-2-(1-pyrrolidiny)cyclohexyl]benzeneacetamides (1-4) a
A New Approach to Hydroazulenes via Olefin Metathesis
Several functionalized diolefins cyclize to hydroazulenes (among others) via olefin metathesis with CH3ReO3.These conversions are regioselective and occur with high diastereoselectivity.
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
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Paragraph 0506
(2016/06/28)
USE OF PYRAZOLOBENZOXAZINES IN METHOD OF TREATING CEREBRAL SENESCENCE AND CEREBRAL HYPOXIN
Novel pyrazolobenzoxazines of the formula STR1 wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkylalkyl or 4 to 7 carbon atoms, alkenyl and alkynyl of 3 to 5 carbon atoms with the proviso that the multiple
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(2008/06/13)
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