Synthesis and Chemical Modification of Homoseryl Peptides
The readily synthesised N,O-ditritylhomoserine (4) was used for the efficient incorporation of homoserine (1) into peptides; the derived homoseryl peptides were transformed into peptides of canaline and 1,4-diaminobutyric acid using the Mitsunobu reaction.
Application of the Trt and Fmoc Groups for the Protection of Polyfunctional α-Amino Acids
Simple methods for the preparation of ditrityl amino acids 3 and their application for the synthesis of the peptides 9-27 are described.Selective detritylation of 3 and of the synthesized ditrityl peptides is achieved with 1percent trifluoroacetic acid in dichloromethane.The resulting Nα-detritylated amino acids 5 were converted into the corresponding fluorenylmethoxycarbonyl amino acids 6 under Schotten-Baumann conditions using fluorenylmethyl chloroformate.