- A new synthetic approach to phosphatidylethanolamine
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A new synthetic method for phosphatidylethanolamine head group was developed via ring-opening of cyclic dioxaphospholane 2 with sodium azide and subsequent hydrogenation. The advantage of this strategy included short reaction steps, readily available materials and good yields.
- Song, Yang,Yuan, Wei,Luo, Yu,Lu, Wei
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- Preparation method of disaturated acyl phosphatidylethanolamine
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The invention discloses a preparation method of disaturated acyl phosphatidylethanolamine, relates to the field of compound preparation, and aims at solving the problems of low yield and high cost ofan existing synthesis method of disaturated acyl phosphatidylethanolamine, wherein the preparation method comprises the following steps: (1) carrying out phosphorylation reaction by using a one-pot method to generate a compound I; (2) mixing the compound I with acid, and carrying out hydrolysis reaction to generate a compound II; (3) carrying out esterification reaction on the compound II and saturated chain acid, namely myristic acid, palmitic acid and stearic acid to generate a compound III; (4) mixing the compound III with DBU, namely 1,8-diazabicyclo undec-7-ene, and carrying out a deprotection reaction to generate a compound IV; and (5) mixing the compound IV with zinc powder and acetic acid, and carrying out a deprotection reaction to generate the disaturated acyl phosphatidylethanolamine. The method is short in synthetic route, mild in reaction condition, wide in application range and high in yield.
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Paragraph 0101-0105
(2020/07/07)
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- A diacyl phosphatidyl ethanolamine preparation method (by machine translation)
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The invention provides a diacyl phosphatidyl ethanolamine preparation method, comprises the following steps: (1) solvent and organic/inorganic alkali under the action of, the formula I compound and phosphorus reagent undergo the substitution reaction, formula a intermediate 1; (2) in the same reaction system, intermediate 1 of an organic/inorganic the presence of an alkali, with 2 - (N - [...] carbonyl amino) ethanol or N - Boc protection of the ethanolamine undergo the substitution reaction, formula b intermediate 2; (3) in the same reaction system, intermediate 2 under the action of the oxidizing agent in the oxidation reaction, the compound of formula II; (4) the formula II compound in the solvent, under the action of alkali, phospholipid base hydrolysis, formula III compound. The advantage of this invention is characterized in that: the invention only needs two-step synthesis of the target product can be obtained, and the method is easy to control conditions, after treatment is simple, less side reaction, high yield, consistent with the requirements of industrial production. (by machine translation)
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Paragraph 0081; 0082; 0083; 0087; 0091
(2018/11/22)
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- Synthesis and properties of photoactivatable phospholipid derivatives designed to probe the membrane-associate domains of proteins
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The total syntheses of photoactivatable phospholipidic probes 1 and 2 are described. These probes contain either an aryldiazonium function at their polar head (probes 1a and 1b) or an diazocyclohexadienonyl group attached to the end of one fatty acid side chain (probe 2) and have been designed to probe the lipid/water interface and the hydrophobic core of the membrane, respectively. The synthetic schemes include the possibility of incorporating a radio-labeled atom (tritium) for further labeling investigations. Both probes were stable in the dark under physiological conditions and could be efficiently photodecomposed at wavelengths above 300 nm, leading to the generation of highly reactive species, aryl cations and cyclohexadienonyl carbene, respectively. In addition, these probes displayed UV-absorption spectra which are compatible with tryptophan-mediated energy transfer photoactivation, which can lead potentially to an efficient mapping of the membrane-associate protein domains.
- Alcaraz, Marie-Lyne,Peng, Ling,Klotz, Philippe,Goeldner, Maurice
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p. 192 - 201
(2007/10/03)
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