- A solid-phase synthetic route to N-acylated α-alkyl-D,L-homoserine lactones
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A synthetic route to N-acylated α-alkyl-D,L-homoserine lactones was established using solid-phase unnatural peptide synthesis (UPS) and combinatorial chemistry. The application of UPS methodology allowed access to racemic N-acylated homoserine lactones (D,L-AHLs) and their α-alkyl structural analogs (α-R1-D,L-AHLs). The synthesis and characterization of a library of five D,L-AHLs and ten α-R1-D,L-AHLs prepared from resin-bound amino acids is reported.
- Ali, Ahmed I. M.,O'Donnell, Martin J.,Samaritoni, J. Geno,Scott, William L.
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supporting information
(2020/09/04)
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