Pyridinethiones. XI. Diastereoselective Aldol Condensations with 2(1H)-Pyridones, 2(1H)-Pyridinethiones, and the Crystal Structure of 3-(1-Hydroxy-2-methyl-3-oxo-3-(4-chlorophenyl)propyl-1-isopropyl-2(1H)-pyridinethione.
Aldol condensation of 3-formyl-2(1H)-pyridinethiones and the corresponding pyridones with ketones such as acetophenones in aqueous base yields 3-hydroxy-1-propanones in high yields.Reaction with propiophenones showed this reaction to be highly diastereose