- Synthesis and spectral characterization of ternary complexes of oxovanadium(IV) containing some acid hydrazones and 2,2′-bipyridine
-
An interesting series of heterocyclic base adducts of oxovanadium(IV) complexes have been synthesized by the reaction of vanadium(IV) oxide acetylacetonate with some hydrazones (H2L) in the presence of a heterocyclic base 2,2′-bipyridine. The c
- Sreeja,Kurup, M.R. Prathapachandra
-
-
Read Online
- Cytotoxic homoleptic Ti(iv) compounds of ONO-type ligands: synthesis, structures and anti-cancer activity
-
Eight Ti(iv) compounds 1-8, of the type [Ti(Ln)2] where Ln is a variously substituted dianionic tridentate acylhydrazone, were synthesized by reacting the appropriate hydrazide with 2-hydroxybenzaldehyde or 2′-hydroxyaceto
- Manne, Rajesh,Miller, Maya,Duthie, Andrew,Guedes Da Silva, M. Fátima C.,Tshuva, Edit Y.,Basu Baul, Tushar S.
-
p. 304 - 314
(2019/01/04)
-
- Acid–Base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide
-
A series of aroylhydrazones were synthesized from nicotinic acid hydrazide and differently substituted benzaldehydes. The protonation constants of the 12 resulting hydrazones, as well as of the starting compounds, were determined in methanol/water 1/1 mix
- Benkovi?,Kontrec,Tomi?i?,Budimir,Gali?
-
p. 1227 - 1245
(2016/08/30)
-
- Regioselective quadruple domino aldolization/aldol condensation/Michael/ SNAr-cyclization: Construction of hexacyclic indeno-fused C-nor-D-homo-steroid frameworks
-
An operationally simple and highly atom-economic anionic quadruple domino reaction sequence for the synthesis of hexacyclic indeno-fused naphthalene/quinoline molecules having structural resemblance with the C-nor-D-homo-steroid nucleus has been developed. Promoter and solvent specificity, regioselectivity and mechanistic details were experimentally established. Catalyst concentration and solvent dependent switching of domino steps creating four new C-C bonds are discussed.
- Chanda, Tanmoy,Chowdhury, Sushobhan,Ramulu, B. Janaki,Koley, Suvajit,Jones, Raymond C.F.,Singh, Maya Shankar
-
p. 2190 - 2194
(2014/03/21)
-
- Acylhydrazide schiff bases: Synthesis and antiglycation activity
-
Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 μM), 27 (IC50 = 234.83 ± 10.28 μM), 2 (IC50 = 240.99 ± 4.2 μM), and 14 (IC50 = 276.2 ± 2.3 μM) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 ± 1.5 μM). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques.
- Khan, Khalid Mohammed,Taha, Muhammad,Rahim, Fazal,Fakhri, Muhammad Imran,Jamil, Waqas,Khan, Momin,Rasheed, Saima,Karim, Aneela,Perveen, Shahnaz,Choudhary, Mohammad Iqbal
-
p. 929 - 937
(2013/07/26)
-
- Acylhydrazide Schiff bases: DPPH radical and superoxide anion scavengers
-
Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25-473.59 μM. Compounds 8, 2, and 10 have IC50 values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 μM, respectively. Standard npropylgallate showed an IC50 value 30.12 ± 0.27 μM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6-450.89 μM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 ± 1.6 μM).
- Khan, Khalid Mohammed,Taha, Muhammad,Naz, Farzana,Siddiqui, Salman,Ali, Sajjad,Rahim, Fazal,Perveen, Shahnaz,Choudhary, M. Iqbal
-
p. 705 - 710
(2012/09/08)
-
- Nicotinic acid benzylidene/phenyl-ethylidene hydrazides: Synthesis, antimicrobial evaluation and QSAR studies
-
A series of nicotinic acid hydrazides (1-19) was synthesized and tested in vitro for antimycobacterial, antiviral, antibacterial and antifungal activities. The antimycobacterial activity results indicated that the presence of electron withdrawing halo groups improved the antimycobacterial activity. The antiviral evaluation showed that none of the synthesized derivatives inhibited the replication of viruses at subtoxic concentrations, except compounds 9 and 12. The antimicrobial screening results demonstrated that compounds having methoxy and 2-hydroxy naphthalene substituents were the most active ones against tested microbial strains. QSAR investigations revealed that multi-target QSAR models were found to be more effective in describing the antimicrobial activity than one-target QSAR models.
- Narang, Rakesh,Narasimhan, Balasubramanian,Sharma, Sunil,Sriram, Dharmarajan,Yogeeswari, Perumal,De Clercq, Erik,Pannecouque, Christophe,Balzarini, Jan
-
p. 733 - 749
(2012/05/05)
-